Single molecular imaging and recognition in liquid by combining infrared spectroscopy and atomic force microscopy

我们开发了调频原子力显微镜（FM-AFM），该显微镜能够使用中心有空心的平面型扫描仪从样品底部照射聚焦的中红外光。我们也取得了显着的改进，在FM-AFM力灵敏度使用一个小悬臂梁来检测表面性能的细微变化引起的红外光的照射。我们通过对相分离聚苯乙烯- pmma嵌段共聚物薄膜进行成像，证明了该显微镜的分子识别能力。

We have developed frequency modulation atomic force microscope(FM-AFM) with a capability of irradiating a focused mid-infrared light from the bottom of the sample using a flat-type scanner with a hollow at the center. We have also achieved a significant improvement in the FM-AFM force sensitivity using a small cantilever to detect a subtle change in the surface property caused by the irradiation of an infrared light. We have demonstrated the molecular recognition capability of the developed microscope by imaging a phase-separated polystyrene-PMMA block copolymer thin film.