Establishment of the systems that regulate the activity of tumor-related factors for tumor suppression

我们发现了肿瘤相关因子的新的分子机制。我们还建立了可渗透性肿瘤抑制因子的表达系统，为肿瘤抑制的蛋白治疗奠定了基础。(1)对与肿瘤生长相关的转录因子DP-1的蛋白质稳定性具有重要意义的“Stabilon”基序的鉴定。(2)发现SOCS 7和TRIP 6的新同种型抑制TRIP 6介导的LPA信号转导。(3)E.杆菌细胞渗透性RAR α、SOCS-3、p53和SOCS-2的表达系统。

We discovered the newly molecular mechanisms of tumor-related factors. We also established that the expression system of cell-permeable tumor suppressors for the protein therapy of tumor suppression.(1) Identification of "Stabilon" motif that is significant for protein stability of transcription factor DP-1 concerned with tumor growth.(2) Discovery of the suppression of TRIP6-mediated LPA signal transduction by SOCS7 and new isoforms of TRIP6.(3) Establishment of E. coli. expression system of cell-permeable RARa, SOCS-3, p53 and SOCS-2.