Elucidation of mechanism for development of cerebrovascular diseases associated with oral bacteria and pursuit of preventive approach

将引起龋齿的致病菌变形链球菌（Streptococcus mutans）的特定菌株注射到大脑中动脉光化学损伤的小鼠颈静脉中，导致脑出血发展。这些突变链球菌在细胞表面具有120 kda的胶原结合蛋白（Cnm蛋白），可抑制血小板聚集特性。此外，研究发现脑出血患者中cnm阳性变形链球菌的检出率明显高于健康人。

Infection with specific strains of Streptococcus mutans, a pathogen of dental caries, by injection into the jugular veins of mice with a photochemically-injured middle cerebral artery resulted in cerebral hemorrhage development. These S. mutans strains possess a 120-kDa collagen-binding protein(Cnm protein) on the cell surface, which inhibits platelet aggregation properties. In addition, the detection rate of Cnm-positive S. mutans strains in patients with a cerebral hemorrhage has been found to be significantly higher than that in healthy individuals.