Ion-specific biological effect of heavy ion near the Bragg peak

布拉格峰附近重离子的离子特异性生物效应

• 批准号: 21710065
• 负责人: KONISHI Teruaki
• 金额: $ 2.91万
• 依托单位: National Institute of Radiological Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21710065/
• 关键词: 重粒子イオン; 細胞致死; DNA二本鎖切断; DNA修復; ブラッグピーク; 切断末端; イオントラック; 重粒子線; 細胞応答

Heavy-ions are in practical use as a radiation source for cancer-therapy, which is now one of the most effective techniques for treatments. In this work, we investigated the biological effectiveness of heavy ion near the Bragg peak, which region shows the drastic increase of energy deposition. We quantitatively analyzed the cell inactivation and DSB induction rate and demonstrated the systematic correlation of these biological effects between the physical properties of the ion. We also found that most of the induced DSBs were irreparable, which was due to the complexity of DNA damage. In addition, we showed evidence on the structural difference of DSB termini end depending on ion species.

重离子作为癌症治疗的辐射源已在实际应用中，这是目前最有效的治疗技术之一。在本工作中，我们研究了重离子在布拉格峰附近的生物效应，该区域显示了能量沉积的急剧增加。我们定量分析了细胞失活和DSB诱导率，并证明了这些生物效应之间的系统相关性的物理性质的离子。我们还发现，大多数诱导的DSB是不可修复的，这是由于DNA损伤的复杂性。此外，我们还发现DSB末端的结构差异取决于离子种类的证据。

项目成果

ブラッグピーク近傍の重粒子イオンによる細胞致死効果の測定

测量布拉格峰附近重粒子离子的细胞杀伤作用

• 发表时间: 2009
• 作者: 小西輝昭;他
• 通讯作者: 他

Visualization of Heavy Ion Tracks by Labeling 3′-OH Termini of Induced DNA Strand Breaks

• DOI: 10.1269/jrr.10097
• 发表时间: 2011-07-01
• 期刊: JOURNAL OF RADIATION RESEARCH
• 影响因子: 2
• 作者: Konishi, Teruaki;Takeyasu, Akihiro;Hieda, Kotaro
• 通讯作者: Hieda, Kotaro