Ion-specific biological effect of heavy ion near the Bragg peak

重离子正被实际用作癌症治疗的放射源，这是目前最有效的治疗技术之一。在这项工作中，我们研究了重离子在Bragg峰附近的生物有效性，该区域显示出能量沉积的急剧增加。我们定量地分析了细胞失活和DSB诱发率，并证明了这些生物效应与离子的物理性质之间的系统相关性。我们还发现，大多数诱导的双链断裂是不可修复的，这是由于DNA损伤的复杂性。此外，我们还证明了DSB末端的结构随离子种类的不同而不同。

Heavy-ions are in practical use as a radiation source for cancer-therapy, which is now one of the most effective techniques for treatments. In this work, we investigated the biological effectiveness of heavy ion near the Bragg peak, which region shows the drastic increase of energy deposition. We quantitatively analyzed the cell inactivation and DSB induction rate and demonstrated the systematic correlation of these biological effects between the physical properties of the ion. We also found that most of the induced DSBs were irreparable, which was due to the complexity of DNA damage. In addition, we showed evidence on the structural difference of DSB termini end depending on ion species.