Protective effect of neurosteroids on developmental brains
Protective effect of neurosteroids on developmental brains
批准号:
22310041
负责人:
YAMAZAKI Takeshi
金额:
$11.9万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
新合成雌二醇可减弱甲基汞或三丁基锡对大鼠海马器官型切片的神经毒性作用。神经类固醇的自我保护功能可能是大脑对神经毒物具有选择性敏感性的机制之一。研究了三丁基锡的神经毒性机制、孕酮和异孕酮的神经保护作用以及甾体激素在大鼠脑内的分布。
英文摘要
Neurotoxic effect of methylmercury or tributyltin was attenuated by de novosynthesized estradiol in rat hippocampal organotypic slice culture. The self-protective function of the neurosteroid might be one of the possible mechanisms for the selective sensitivity of the brain to neurotoxicants. Neurotoxic mechanism of tributyltin, neuroprotective effect of progesterone and allopregnanolone, and distribution of steroids in rat brain were studied.
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ラット海馬シナプスにおける性ホルモンの合成と局所分泌
大鼠海马突触性激素的合成和局部分泌
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[北條泰嗣, 肥後心平, 向井秀夫, 原田信広, 山崎岳, 木本哲也, 川戸佳]
通讯作者:
川戸佳
Effect of housing conditions on neurotoxicity of trimethyltin in ratbrain
饲养条件对三甲基锡对大鼠脑神经毒性的影响
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[大山勤, 崎本裕也, 鬼崎聖大, 小山友香, 濱崎佐和子, 野崎香菜子, 椋田崇生, 坂田省吾, 石田敦彦, 山崎岳]
通讯作者:
山崎岳
CoPK32 is a novel stress-responsive protein kinase in the mushroom Coprinopsis cinerea
CoPK32 是蘑菇灰鬼伞 (Coprinopsis cinerea) 中的一种新型应激响应蛋白激酶
DOI:
10.1016/j.bbagen.2011.03.018
发表时间:
2011
期刊:
Biochimica et Biophysica Acta
影响因子:
--
作者:
[遠藤圭太, 荒川圭太, 藤川清三, 遠藤圭太, 遠藤圭太, 遠藤圭太, K.Endoh, K.Endoh, Keisuke Kaneko]
通讯作者:
Keisuke Kaneko
Contribution of reductase activity to quinone toxicity in three kinds of hepatic cells.
还原酶活性对三种肝细胞醌毒性的贡献。
DOI:
10.1248/bpb.35.634
发表时间:
2012
期刊:
Biological & pharmaceutical bulletin
影响因子:
2
作者:
[Y. Ishihara, K. Tsuji, Satomi Ishii, Kyoko Kashiwagi, N. Shimamoto]
通讯作者:
N. Shimamoto
Increased expression of c-fos by ERK activation under sustained oxidative stress elicits BimEL upregulation and hepatocyte apoptosis
持续氧化应激下 ERK 激活导致 c-fos 表达增加,引发 BimEL 上调和肝细胞凋亡
DOI:
--
发表时间:
2011
期刊:
FEBS J
影响因子:
5.4
作者:
[Ishihara Y, Ito F, Shimamoto N]
通讯作者:
Shimamoto N
共 46 条
Development and Problems of the Transboundary Community in East Asia
-
批准号:15K01879
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2015
-
负责人:YAMAZAKI Takeshi
-
依托单位:
Advance and validation of leaf-wetness estimating method using meteorological data
-
批准号:24540467
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.24万
-
财政年份:2012
-
负责人:YAMAZAKI Takeshi
-
依托单位:
South China and Vietnam during Ming and Qing period
-
批准号:20720185
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.58万
-
财政年份:2008
-
负责人:YAMAZAKI Takeshi
-
依托单位:
Basic studies on cut marks on animal bones excavated from archeological sites
-
批准号:20800087
-
项目类别:Grant-in-Aid for Young Scientists (Start-up)
-
资助金额:$2.09万
-
财政年份:2008
-
负责人:YAMAZAKI Takeshi
-
依托单位:
Rent Seeking and Endogenous Tariff Rate
-
批准号:19530151
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.75万
-
财政年份:2007
-
负责人:YAMAZAKI Takeshi
-
依托单位:
Reverse Mathematics and Models of Arithmetic
-
批准号:19740042
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.23万
-
财政年份:2007
-
负责人:YAMAZAKI Takeshi
-
依托单位:
Sensitive assay for disturbance of brain function by environmental pollutants at low concentrations
-
批准号:18510058
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.68万
-
财政年份:2006
-
负责人:YAMAZAKI Takeshi
-
依托单位:
Understanding of heat and water balance, and evapotranspiration characteristics on Asian monsoon area with one-dimensional land surface models
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批准号:14340142
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$2.69万
-
财政年份:2002
-
负责人:YAMAZAKI Takeshi
-
依托单位:
Researches in heat budget for snow accreting boreal forests
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批准号:08640541
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.41万
-
财政年份:1996
-
负责人:YAMAZAKI Takeshi
-
依托单位:
海外基金