Analysis of the outer membrane BAM complex
Analysis of the outer membrane BAM complex
批准号:
22370044
负责人:
J・R・H Tame
金额:
$12.15万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
Gram negative bacteria require the BAM complex for the insertion of membrane proteins into the outer membrane. This essential complex consists of five proteins, the large transmembrane barrel being BamA. BamA carries five POTRA domains at its N terminus which interact with other proteins in the complex. Only BamA and BamD are essential, but the roles of these proteins is unknown. We have solved the crystal structure of an outer membrane protein, Hbp, and studied the interaction between BamC and BamD. The Hbp beta-barrel is a substrate of BAM, but the interactions between the two are unclear. We have shown that BamC and BamD interact to give a flexible complex.
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DOI:
10.1038/359458a0
发表时间:
1992
期刊:
Nature
影响因子:
64.8
作者:
[K. James]
通讯作者:
K. James
DOI:
10.1107/s0907444912029459
发表时间:
2012-11-01
期刊:
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
影响因子:
--
作者:
[Noguchi, Hiroki, Campbell, Kevin L., Tame, Jeremy R. H.]
通讯作者:
Tame, Jeremy R. H.
Order and disorder in the domain organization of the plasmid partition protein KorB
质粒分区蛋白 KorB 结构域组织的有序与无序
DOI:
--
发表时间:
2010
期刊:
J Biol Chem
影响因子:
4.8
作者:
[Rajasekar, K., Muntaha, S. T., Tame, J. R. H., Kommareddy, S., Morris, G., Wharton, C. W., Thomas, C. M., White, S. A., Hyde, E. I. & Scott, D. J]
通讯作者:
D. J
Beyond structure
超越结构
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[藤田融, 中西義信, 白土明子, 永長一茂, Jeremy Tame]
通讯作者:
Jeremy Tame
Structural insight into the essential subunit contacts of the in fluenza virus RNA polymerase
流感病毒 RNA 聚合酶重要亚基接触的结构洞察
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[奥村文彦, 奥村晶子, 畠山鎮次, ザン・ドンガー, 嘉村巧, 竹内将人,坂根郁夫, 中西義信, Jeremy Tame]
通讯作者:
Jeremy Tame
共 26 条
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