Simulation study of biomolecular motors: Structural analysis of regulation mechanisms of chemical reaction by motor movements

点击翻译按钮获取中文摘要

As a working principle of biomolecular motors, it is important to understand the regulation of chemical reactions by motor movements and conformational changes in enzymes. Here, we studied theoretically how a double-headed kinesin, one of the best characterized molecular motors, can regulate motions of two heads and addressed what is the structural basis for this cooperation. We found that the nucleotide-dependent tensions between the two heads are the fundamentals, and by that, unidirectional and chemically tight coupling between two heads are realized.