Multipotential stem cell-like nature of bone marrow-derived macrophages accumulated in lesion core of acute and severe brain injuries.

许多骨髓来源的巨噬细胞被发现聚集在中风和创伤性脑损伤的病变核心。由于大多数细胞表达脑内多能细胞标记物NG2硫酸软骨素蛋白多糖和巨噬细胞标记物IBA1，它们被称为BINCs(脑IBA1/NG2^细胞)。BINCs通过释放神经保护性生长因子，清除变性细胞和组织，发挥神经保护作用，促进损伤组织的再生和修复。我们发现，注射细胞因子混合物(IL3和GM-CSF)可显著改善创伤性脑损伤和帕金森病。

Many bone marrow-derived macrophages were found to accumulate in lesion cores of stroke and traumatic brain injuries. Because most of the cells expressed a multipotent cell marker in the brain, NG2 chondroitin sulfate proteoglycan as well as a macrophage marker Iba1, they were termed BINCs (Brain Iba1^+/NG2^+Cells). BINCs exerted neuroprotective actions and promoted regeneration and restoration of injured tissue by releasing neuroprotective growth factors and scavenging degenerated cellsand tissues. We found that injection of a cytokine mixture (IL3 and GM-CSF) markedly ameliorated traumatic brain injury and Parkinson’s disease.