Determination of cell type(s) that should be transplanted into lesion core of the brain for better outcome

确定应移植到大脑病变核心以获得更好结果的细胞类型

• 批准号: 23659688
• 负责人: TANAKA Junya
• 金额: $ 2.33万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659688/
• 关键词: 脳梗塞; マイクログリア; 脳損傷; アストロサイト; 細胞移植; マクロファージ; 骨髄; BINCs

To determine cell type(s) that should be transplanted into the lesion core of ischemic and traumatic brain injuries with an aim to ameliorate the outcomes, several kinds of cultured neural cells including microglial cells, astrocytes, and brain macrophages isolated from ischemic lesion core of rat brains. Consequently,it was found that most of transplanted cells were eliminated by phagocytic macrophages in spite of the isotransplantation. Only BINCs were transplantable into the ischemic core, and their transplantation may be appeared therapeutically effective.

为了确定应移植到缺血性和创伤性脑损伤的病变核心中的细胞类型，以改善结果，从大鼠脑缺血性病变核心中分离出几种培养的神经细胞，包括小胶质细胞、星形胶质细胞和脑巨噬细胞。结果发现，尽管同种移植，但大多数移植细胞被吞噬性巨噬细胞清除。只有BINCs可移植到缺血核心，其移植可能出现治疗效果。

项目成果

Response of glial cells in and around ischemic lesion of rats that were subjected to transient middle cerebral artery occlusion : the involvement of IL-18

短暂大脑中动脉闭塞大鼠缺血性病变内部及周围胶质细胞的反应：IL-18的参与

• 发表时间: 2013
• 作者: Ayano Mise;Kana Sugimoto;Ryutaro Nishioka;Hisaaki Takahashi;Hajime Yano;Junya Tanaka
• 通讯作者: Junya Tanaka

神経細胞傷害に対するグリア細胞の反応:ラット6-OHDA負荷パーキンソン病モデルを用いた検討

胶质细胞对神经元损伤的反应：使用加载 6-OHDA 的大鼠帕金森病模型进行的研究

• 发表时间: 2011
• 作者: 田中潤也;他
• 通讯作者: 他

A cytokine mixture of GM-CSF and IL-3 that induces a neuroprotective phenotype of microglia leading to amelioration of (6-OHDA)-induced Parkinsonism of rats.

• DOI: 10.1002/brb3.11
• 发表时间: 2011-09
• 期刊: BRAIN AND BEHAVIOR
• 影响因子: 3.1
• 作者: Choudhury, Mohammed Emamussalehin;Sugimoto, Kana;Kubo, Madoka;Nagai, Masahiro;Nomoto, Masahiro;Takahashi, Hisaaki;Yano, Hajime;Tanaka, Junya
• 通讯作者: Tanaka, Junya

脳梗塞巣に集積するマクロファージの役割とその治療的利用

脑梗塞病灶中聚集的巨噬细胞的作用及其治疗用途

• 发表时间: 2012
• 作者: 田中潤也;杉本香奈;西原佑;高橋寿明;矢野元
• 通讯作者: 矢野元

Invasion of monocytes/macrophages into ischemic lesion of rat brain: involvement of chemokines and their receptors

单核/巨噬细胞侵袭大鼠脑缺血灶：趋化因子及其受体的参与

• 发表时间: 2013
• 作者: Yudai Ohara;Kana Sugimoto;Ryutaro Nishioka;Hisaaki Takahashi;Hajime Yano、Nari Tei;Yoshiaki Kumon;Takanori Ohnishi;Junya Tanaka
• 通讯作者: Junya Tanaka