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Determination of cell type(s) that should be transplanted into lesion core of the brain for better outcome

Determination of cell type(s) that should be transplanted into lesion core of the brain for better outcome
确定应移植到大脑病变核心以获得更好结果的细胞类型
批准号:
23659688
负责人:
TANAKA Junya
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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项目成果

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中文摘要
翻译
为确定缺血性和外伤性脑损伤损伤核心应移植的细胞类型,以改善其预后,本研究从大鼠脑缺血性损伤核心中分离出几种培养的神经细胞,包括小胶质细胞、星形胶质细胞和脑巨噬细胞。结果发现,尽管进行了等移植,但大部分移植细胞被吞噬性巨噬细胞清除。只有BINCs被移植到缺血核心,它们的移植可能显示出治疗效果。
英文摘要
To determine cell type(s) that should be transplanted into the lesion core of ischemic and traumatic brain injuries with an aim to ameliorate the outcomes, several kinds of cultured neural cells including microglial cells, astrocytes, and brain macrophages isolated from ischemic lesion core of rat brains. Consequently,it was found that most of transplanted cells were eliminated by phagocytic macrophages in spite of the isotransplantation. Only BINCs were transplantable into the ischemic core, and their transplantation may be appeared therapeutically effective.
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会议论文
Response of glial cells in and around ischemic lesion of rats that were subjected to transient middle cerebral artery occlusion : the involvement of IL-18
短暂大脑中动脉闭塞大鼠缺血性病变内部及周围胶质细胞的反应:IL-18的参与
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Ayano Mise, Kana Sugimoto, Ryutaro Nishioka, Hisaaki Takahashi, Hajime Yano, Junya Tanaka]
通讯作者: Junya Tanaka
神経細胞傷害に対するグリア細胞の反応:ラット6-OHDA負荷パーキンソン病モデルを用いた検討
胶质细胞对神经元损伤的反应:使用加载 6-OHDA 的大鼠帕金森病模型进行的研究
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [田中潤也, 他]
通讯作者:
DOI: 10.1002/brb3.11
发表时间: 2011-09
期刊: BRAIN AND BEHAVIOR
影响因子: 3.1
作者: [Choudhury, Mohammed Emamussalehin, Sugimoto, Kana, Kubo, Madoka, Nagai, Masahiro, Nomoto, Masahiro, Takahashi, Hisaaki, Yano, Hajime, Tanaka, Junya]
通讯作者: Tanaka, Junya
脳梗塞巣に集積するマクロファージの役割とその治療的利用
脑梗塞病灶中聚集的巨噬细胞的作用及其治疗用途
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [田中潤也, 杉本香奈, 西原佑, 高橋寿明, 矢野元]
通讯作者: 矢野元
10
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    • 财政年份:
      1998
    • 负责人:
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    • 依托单位:
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