Identification and targeting of the functional domains of malaria parasite's molecules involved in the erythrocyte invasion
Identification and targeting of the functional domains of malaria parasite's molecules involved in the erythrocyte invasion
批准号:
22390079
负责人:
KANEKO Osamu
金额:
$12.06万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
We found that RON5 was a component of AMA1-RON complex, a target of the growth inhibitory antibodies, and was expressed at both merozoite and sporozoite stages of the rodent malaria parasite. We also identified the region of RhopH1A responsible for the complex formation. We established time-lapse imaging analysis of the erythrocyte invasion by rodent malaria parasite and found that morphological change of the released merozoite was required for the erythrocyte invasion.
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Expression of PyRON5, a Plasmodium yoelii rhoptry neck protein inmerozoite and sporozoite
PyRON5(一种约氏疟原虫棒状颈蛋白)在裂殖子和子孢子中的表达
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Mutungi JK, Kaewthamasorn M, Culleton R,Sakaguchi M, Yahata K, Kaneko O]
通讯作者:
Kaneko O
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Yahata K, Kaneko O]
通讯作者:
Kaneko O
Expression of PyRON5, a Plasmodium yoelii rhoptry neck protein in merozoite and sporozoite
PyRON5(一种约氏疟原虫棒状颈蛋白)在裂殖子和子孢子中的表达
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Tsuchiya, K, Mutungi JK]
通讯作者:
Mutungi JK
DOI:
10.1371/journal.pone.0050780
发表时间:
2012
期刊:
PloS one
影响因子:
3.7
作者:
[Yahata K, Treeck M, Culleton R, Gilberger TW, Kaneko O]
通讯作者:
Kaneko O
Characterisation of PyRON5, A Plasmodium yoelii rhoptry neck protein
PyRON5(约氏疟原虫菱形颈蛋白)的表征
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Mutungi JK, Kaewthamasorn M, Culleton R, Sakaguchi M, Yahata K, Kaneko O]
通讯作者:
Kaneko O
共 13 条
Signaling mechanism of the apical organelle discharge by malaria parasites during erythrocyte invasion
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批准号:19H03461
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.15万
-
财政年份:2019
-
负责人:KANEKO Osamu
-
依托单位:
Development of a live attenuated monkey malaria vaccine with enhanced antigenicity
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批准号:17K19566
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项目类别:Grant-in-Aid for Challenging Research (Exploratory)
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资助金额:$4.16万
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财政年份:2017
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负责人:KANEKO Osamu
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依托单位:
Signaling in malaria parasites during erythrocyte invasion
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批准号:16H05184
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.23万
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财政年份:2016
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负责人:KANEKO Osamu
-
依托单位:
Molecular basis of the adaptation of Plasmodium knowlesi to human erythrocytes using mutator parasite lines
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批准号:15K15125
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
-
财政年份:2015
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负责人:KANEKO Osamu
-
依托单位:
Deciphering hypnozoite formation of Plasmodium vivax
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批准号:15H02656
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$26.96万
-
财政年份:2015
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负责人:KANEKO Osamu
-
依托单位:
Mechanism of the tropism switching of monkey malaria to human using Plasmodium knowlesi mutator line
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批准号:25670203
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
-
财政年份:2013
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负责人:KANEKO Osamu
-
依托单位:
Signal transduction during erythrocyte invasion by malaria parasites
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批准号:25293102
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.15万
-
财政年份:2013
-
负责人:KANEKO Osamu
-
依托单位:
Seroepidemiology of the molecules expressed on the Plasmodium vivax-infected erythrocyte surface
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批准号:24406012
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.32万
-
财政年份:2012
-
负责人:KANEKO Osamu
-
依托单位:
Genetic manipulation to generate transgenic Plasmodium vivax invasive to the mature erythrocytes
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批准号:23659215
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2011
-
负责人:KANEKO Osamu
-
依托单位:
Design of data-driven lumped parameter canonical controller for distributed parameter system with its performance analysis
-
批准号:22560442
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.66万
-
财政年份:2010
-
负责人:KANEKO Osamu
-
依托单位:
Population genetics analysis of Plasmodium vivax-infected erythrocyte surface protein PvSTP
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批准号:20406009
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.9万
-
财政年份:2008
-
负责人:KANEKO Osamu
-
依托单位:
On MPUM theory for dynamical systems defined by the rings : Kernel representation approach
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批准号:19760286
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$1.41万
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财政年份:2007
-
负责人:KANEKO Osamu
-
依托单位:
Molecular basis of the intracellular trafficking of the malaria ligands
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批准号:19590428
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2007
-
负责人:KANEKO Osamu
-
依托单位:
Association of the Plasmodium falciparuminfected erythrocyte surface molecule with ist virulence
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批准号:17406009
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.38万
-
财政年份:2005
-
负责人:KANEKO Osamu
-
依托单位:
Development of antisense technique for the malaria parasite
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批准号:17590372
-
项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
-
财政年份:2005
-
负责人:KANEKO Osamu
-
依托单位:
海外基金