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Identification and targeting of the functional domains of malaria parasite's molecules involved in the erythrocyte invasion

Identification and targeting of the functional domains of malaria parasite's molecules involved in the erythrocyte invasion
识别和靶向参与红细胞侵袭的疟疾寄生虫分子的功能域
批准号:
22390079
负责人:
KANEKO Osamu
金额:
$12.06万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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英文摘要
We found that RON5 was a component of AMA1-RON complex, a target of the growth inhibitory antibodies, and was expressed at both merozoite and sporozoite stages of the rodent malaria parasite. We also identified the region of RhopH1A responsible for the complex formation. We established time-lapse imaging analysis of the erythrocyte invasion by rodent malaria parasite and found that morphological change of the released merozoite was required for the erythrocyte invasion.
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Expression of PyRON5, a Plasmodium yoelii rhoptry neck protein inmerozoite and sporozoite
PyRON5(一种约氏疟原虫棒状颈蛋白)在裂殖子和子孢子中的表达
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Mutungi JK, Kaewthamasorn M, Culleton R,Sakaguchi M, Yahata K, Kaneko O]
通讯作者: Kaneko O
Time-lapse imaging of red blood cell invasion by rodent malaria parasites
啮齿动物疟原虫入侵红细胞的延时成像
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Yahata K, Kaneko O]
通讯作者: Kaneko O
Expression of PyRON5, a Plasmodium yoelii rhoptry neck protein in merozoite and sporozoite
PyRON5(一种约氏疟原虫棒状颈蛋白)在裂殖子和子孢子中的表达
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Tsuchiya, K, Mutungi JK]
通讯作者: Mutungi JK
DOI: 10.1371/journal.pone.0050780
发表时间: 2012
期刊: PloS one
影响因子: 3.7
作者: [Yahata K, Treeck M, Culleton R, Gilberger TW, Kaneko O]
通讯作者: Kaneko O
13
    Signaling mechanism of the apical organelle discharge by malaria parasites during erythrocyte invasion
    • 批准号:
      19H03461
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.15万
    • 财政年份:
      2019
    • 负责人:
      KANEKO Osamu
    • 依托单位:
    Development of a live attenuated monkey malaria vaccine with enhanced antigenicity
    • 批准号:
      17K19566
    • 项目类别:
      Grant-in-Aid for Challenging Research (Exploratory)
    • 资助金额:
      $4.16万
    • 财政年份:
      2017
    • 负责人:
      KANEKO Osamu
    • 依托单位:
    Signaling in malaria parasites during erythrocyte invasion
    • 批准号:
      16H05184
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.23万
    • 财政年份:
      2016
    • 负责人:
      KANEKO Osamu
    • 依托单位:
    Molecular basis of the adaptation of Plasmodium knowlesi to human erythrocytes using mutator parasite lines
    • 批准号:
      15K15125
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.41万
    • 财政年份:
      2015
    • 负责人:
      KANEKO Osamu
    • 依托单位:
    海外基金