Identification and targeting of the functional domains of malaria parasite's molecules involved in the erythrocyte invasion
识别和靶向参与红细胞侵袭的疟疾寄生虫分子的功能域
基本信息
- 批准号:22390079
- 负责人:
- 金额:$ 12.06万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2010
- 资助国家:日本
- 起止时间:2010 至 2012
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We found that RON5 was a component of AMA1-RON complex, a target of the growth inhibitory antibodies, and was expressed at both merozoite and sporozoite stages of the rodent malaria parasite. We also identified the region of RhopH1A responsible for the complex formation. We established time-lapse imaging analysis of the erythrocyte invasion by rodent malaria parasite and found that morphological change of the released merozoite was required for the erythrocyte invasion.
我们发现RON 5是AMA 1-罗恩复合物的一个组分,是生长抑制抗体的靶点,并且在啮齿类疟原虫的裂殖子和孢子阶段都表达。我们还确定了负责复合物形成的RhopH 1A区域。我们建立了啮齿类疟原虫侵入红细胞的延时成像分析,发现释放的裂殖子的形态变化是侵入红细胞所必需的。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Expression of PyRON5, a Plasmodium yoelii rhoptry neck protein inmerozoite and sporozoite
PyRON5(一种约氏疟原虫棒状颈蛋白)在裂殖子和子孢子中的表达
- DOI:
- 发表时间:2012
- 期刊:
- 影响因子:0
- 作者:Mutungi JK;Kaewthamasorn M;Culleton R,Sakaguchi M;Yahata K;Kaneko O
- 通讯作者:Kaneko O
Time-lapse imaging of red blood cell invasion by rodent malaria parasites
啮齿动物疟原虫入侵红细胞的延时成像
- DOI:
- 发表时间:2012
- 期刊:
- 影响因子:0
- 作者:Yahata K;Kaneko O
- 通讯作者:Kaneko O
Expression of PyRON5, a Plasmodium yoelii rhoptry neck protein in merozoite and sporozoite
PyRON5(一种约氏疟原虫棒状颈蛋白)在裂殖子和子孢子中的表达
- DOI:
- 发表时间:2012
- 期刊:
- 影响因子:0
- 作者:Tsuchiya;K;Mutungi JK
- 通讯作者:Mutungi JK
Time-lapse imaging of red blood cell invasion by the rodent malaria parasite Plasmodium yoelii.
- DOI:10.1371/journal.pone.0050780
- 发表时间:2012
- 期刊:
- 影响因子:3.7
- 作者:Yahata K;Treeck M;Culleton R;Gilberger TW;Kaneko O
- 通讯作者:Kaneko O
Characterisation of PyRON5, A Plasmodium yoelii rhoptry neck protein
PyRON5(约氏疟原虫菱形颈蛋白)的表征
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:Mutungi JK;Kaewthamasorn M;Culleton R;Sakaguchi M;Yahata K;Kaneko O
- 通讯作者:Kaneko O
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KANEKO Osamu其他文献
KANEKO Osamu的其他文献
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{{ truncateString('KANEKO Osamu', 18)}}的其他基金
Signaling mechanism of the apical organelle discharge by malaria parasites during erythrocyte invasion
红细胞侵袭过程中疟原虫顶端细胞器放电的信号机制
- 批准号:
19H03461 - 财政年份:2019
- 资助金额:
$ 12.06万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of a live attenuated monkey malaria vaccine with enhanced antigenicity
开发具有增强抗原性的猴疟疾减毒活疫苗
- 批准号:
17K19566 - 财政年份:2017
- 资助金额:
$ 12.06万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
Signaling in malaria parasites during erythrocyte invasion
红细胞侵袭过程中疟疾寄生虫的信号传导
- 批准号:
16H05184 - 财政年份:2016
- 资助金额:
$ 12.06万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Molecular basis of the adaptation of Plasmodium knowlesi to human erythrocytes using mutator parasite lines
使用突变寄生虫系使诺氏疟原虫适应人类红细胞的分子基础
- 批准号:
15K15125 - 财政年份:2015
- 资助金额:
$ 12.06万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Deciphering hypnozoite formation of Plasmodium vivax
破译间日疟原虫催眠体的形成
- 批准号:
15H02656 - 财政年份:2015
- 资助金额:
$ 12.06万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Mechanism of the tropism switching of monkey malaria to human using Plasmodium knowlesi mutator line
利用诺氏疟原虫突变株将猴疟疾向人转变的机制
- 批准号:
25670203 - 财政年份:2013
- 资助金额:
$ 12.06万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Signal transduction during erythrocyte invasion by malaria parasites
疟原虫入侵红细胞期间的信号转导
- 批准号:
25293102 - 财政年份:2013
- 资助金额:
$ 12.06万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Seroepidemiology of the molecules expressed on the Plasmodium vivax-infected erythrocyte surface
间日疟原虫感染的红细胞表面表达分子的血清流行病学
- 批准号:
24406012 - 财政年份:2012
- 资助金额:
$ 12.06万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Genetic manipulation to generate transgenic Plasmodium vivax invasive to the mature erythrocytes
基因操作产生侵入成熟红细胞的转基因间日疟原虫
- 批准号:
23659215 - 财政年份:2011
- 资助金额:
$ 12.06万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Design of data-driven lumped parameter canonical controller for distributed parameter system with its performance analysis
数据驱动的分布式参数系统集总参数典型控制器设计及其性能分析
- 批准号:
22560442 - 财政年份:2010
- 资助金额:
$ 12.06万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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10934306 - 财政年份:2015
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$ 12.06万 - 项目类别:
Antigen exposure in utero: impacts on newborn immunity and infectious diseases
子宫内抗原暴露:对新生儿免疫力和传染病的影响
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8789351 - 财政年份:2013
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$ 12.06万 - 项目类别:
Antigen exposure in utero: impacts on newborn immunity and infectious diseases
子宫内抗原暴露:对新生儿免疫力和传染病的影响
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$ 12.06万 - 项目类别:
Antigen exposure in utero: impacts on newborn immunity and infectious diseases
子宫内抗原暴露:对新生儿免疫力和传染病的影响
- 批准号:
8991705 - 财政年份:2013
- 资助金额:
$ 12.06万 - 项目类别:
Antigen exposure in utero: impacts on newborn immunity and infectious diseases
子宫内抗原暴露:对新生儿免疫力和传染病的影响
- 批准号:
8608480 - 财政年份:2013
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