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Application of autophagy to forensic diagnosis -evaluation of autophagy as a novel marker

Application of autophagy to forensic diagnosis -evaluation of autophagy as a novel marker
自噬在法医学诊断中的应用——自噬作为新型标志物的评价
批准号:
22390142
负责人:
KIMURA Akihiko
金额:
$11.81万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010-04-01 至 2014-03-31

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中文摘要
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英文摘要
The function and pattern of appearance of autophagy in the various tissue injury were analyzed in the mouse models. We showed that autophagy was induced in early stage in the kidney of mice administrated with cisplatin, which was a protective response to cisplatin-induced renal injury. We also found that autophagy was induced in the compensatory stage of cardiac hypertrophy.In analysis of autophagy in the skin wound healing process, we found immediate reduction of autophagy in the wound sites,which might be very useful for forensic practice as a novel marker of vitality of skin wound.
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会议论文
Essential roles of CCL3-CCR1 axis in the pathogenesis of antigen-induced arthritis
CCL3-CCR1轴在抗原诱导关节炎发病机制中的重要作用
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Kohga K, Takehara T, 他, Inui K, Ishida Y]
通讯作者: Ishida Y
IFN-γ plays a protective role in pressure overload-induced cardiac hyper trophy
IFN-γ在压力超负荷引起的心脏肥大中发挥保护作用
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [森口茂樹, 喜多紗斗美, 岩本隆宏, 福永浩司, Kimura A]
通讯作者: Kimura A
Absence of IFN-γ accelerates thrombus resolution through enhanced MMP-9 and VEGF expression
IFN-γ 缺失可通过增强 MMP-9 和 VEGF 表达加速血栓溶解
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [H.Nakamura, S.Matoba, E.Iwai-Kanai, M.Kimata, A.Hoshino, M.Nakaoka, M.Katamura, Y.Okawa, Y.Mita, T.Tatsumi, H.Matsubara., Ishida Y]
通讯作者: Ishida Y
Crosstalk between estrogen/estrogen receptor and IL-6/Jak/Stat3 signal in pathogenesis of sodium arsenite -induced renal injury
亚砷酸钠肾损伤发病机制中雌激素/雌激素受体与IL-6/Jak/Stat3信号的串扰
DOI: --
发表时间:
期刊:
影响因子: --
作者: [Kimura A, Ishida Y, Nosaka M, Mukaida N, Kondo T]
通讯作者: Kondo T
30
    Development of novel diagnostic methods for anaphylactic shock based on gene expression
    • 批准号:
      24659339
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.25万
    • 财政年份:
      2012
    • 负责人:
      KIMURA Akihiko
    • 依托单位:
    Establishment of novel forensic diagnostic methods based on biological clock
    • 批准号:
      22659137
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $1.77万
    • 财政年份:
      2010
    • 负责人:
      KIMURA Akihiko
    • 依托单位:
    Molecular mechanism in pathogenesis of arsenic intoxication-toward forensic molecular toxicological clarification-
    • 批准号:
      19390187
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.23万
    • 财政年份:
      2007
    • 负责人:
      KIMURA Akihiko
    • 依托单位:
    Molecular Pathophysiological Mechanism of Arsenic Intoxication-Toward Molecular Forensic Toxicology-
    • 批准号:
      17590582
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.18万
    • 财政年份:
      2005
    • 负责人:
      KIMURA Akihiko
    • 依托单位:
    海外基金