Application of autophagy to forensic diagnosis -evaluation of autophagy as a novel marker

自噬在法医学诊断中的应用——自噬作为新型标志物的评价

• 批准号: 22390142
• 负责人: KIMURA Akihiko
• 金额: $ 11.81万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390142/
• 关键词: autophay; 薬物中毒; 腎障害; 心不全; 皮膚創傷; 法医診断; autophagy; 大動脈瘤; 創傷治癒; 生活反応; オートファジー; プロテアソーム; 心肥大; 皮膚損傷; 体内時計; 法医病理診断; 飢餓

The function and pattern of appearance of autophagy in the various tissue injury were analyzed in the mouse models. We showed that autophagy was induced in early stage in the kidney of mice administrated with cisplatin, which was a protective response to cisplatin-induced renal injury. We also found that autophagy was induced in the compensatory stage of cardiac hypertrophy.In analysis of autophagy in the skin wound healing process, we found immediate reduction of autophagy in the wound sites,which might be very useful for forensic practice as a novel marker of vitality of skin wound.

在小鼠模型中分析自噬在各种组织损伤中的功能和出现模式。我们发现，自噬在顺铂给药小鼠肾脏的早期阶段诱导，这是对顺铂诱导的肾损伤的保护性反应。在分析皮肤创伤愈合过程中的自噬现象时，发现创伤后即刻自噬减少，这可能是一种新的皮肤创伤活力的法医学标记。

项目成果

Essential roles of CCL3-CCR1 axis in the pathogenesis of antigen-induced arthritis

CCL3-CCR1轴在抗原诱导关节炎发病机制中的重要作用

• 发表时间: 2011
• 作者: Kohga K;Takehara T;他;Inui K;Ishida Y
• 通讯作者: Ishida Y

IFN-γ plays a protective role in pressure overload-induced cardiac hyper trophy

IFN-γ在压力超负荷引起的心脏肥大中发挥保护作用

• 发表时间: 2011
• 作者: 森口茂樹;喜多紗斗美;岩本隆宏;福永浩司;Kimura A
• 通讯作者: Kimura A

Crosstalk between estrogen/estrogen receptor and IL-6/Jak/Stat3 signal in pathogenesis of sodium arsenite -induced renal injury

亚砷酸钠肾损伤发病机制中雌激素/雌激素受体与IL-6/Jak/Stat3信号的串扰

• 作者: Kimura A;Ishida Y;Nosaka M;Mukaida N;Kondo T
• 通讯作者: Kondo T

Absence of IFN-γ accelerates thrombus resolution through enhanced MMP-9 and VEGF expression

IFN-γ 缺失可通过增强 MMP-9 和 VEGF 表达加速血栓溶解

• 发表时间: 2011
• 作者: H.Nakamura;S.Matoba;E.Iwai-Kanai;M.Kimata;A.Hoshino;M.Nakaoka;M.Katamura;Y.Okawa;Y.Mita;T.Tatsumi;H.Matsubara.;Ishida Y
• 通讯作者: Ishida Y

皮膚組織におけるautophagyのcircadian rhythmと創傷治癒

皮肤组织自噬和伤口愈合的昼夜节律

• 发表时间: 2013
• 作者: Kimura A;Ishida Y;Nosaka M;Kuninaka Y;Mukaida N;Kondo T.;近藤稔和,木村章彦,石田裕子,野坂みずほ,國中由美,川口真理子
• 通讯作者: 近藤稔和,木村章彦,石田裕子,野坂みずほ,國中由美,川口真理子