Establishment of novel forensic diagnostic methods based on biological clock

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Biological clock exists in most tissues and is involved in their homeostasis. Malfunction of biological clock can cause various diseases. In this study, we examined the possibility that forensic diagnosis can be performed by analysis of biological clock in the tissues. We found that significant reduction of clock gene expression in the hypertrophic heart, kidney damaged with a toxic compound and injured skin tissue, suggesting that biological clock in the damaged tissues might be a novel diagnostic marker in forensic medicine.