Establishment of novel forensic diagnostic methods based on biological clock

基于生物钟的新型法医学诊断方法的建立

• 批准号: 22659137
• 负责人: KIMURA Akihiko
• 金额: $ 1.77万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659137/
• 关键词: 体内時計; 法医診断; 時計遺伝子; Real-time PCR; 心肥大; 心不全; 腎炎; 皮膚損傷; 法医病理診断

Biological clock exists in most tissues and is involved in their homeostasis. Malfunction of biological clock can cause various diseases. In this study, we examined the possibility that forensic diagnosis can be performed by analysis of biological clock in the tissues. We found that significant reduction of clock gene expression in the hypertrophic heart, kidney damaged with a toxic compound and injured skin tissue, suggesting that biological clock in the damaged tissues might be a novel diagnostic marker in forensic medicine.

生物钟存在于大多数组织中，并参与其稳态。生物钟失调会引起各种疾病。本研究探讨了通过组织生物钟分析进行法医学诊断的可能性。我们发现，在肥大的心脏，肾脏损伤的有毒化合物和损伤的皮肤组织中，时钟基因的表达显着减少，这表明在受损组织中的生物钟可能是一种新的法医学诊断标志物。

项目成果

Application of the biological clock-based method for estimating the time of death to forensic practices

基于生物钟的死亡时间推算方法在法医实践中的应用

• 作者: Kimura A;Ishida Y;Nosaka M;Kuninaka Y;Kawaguchi M;Kondo T
• 通讯作者: Kondo T

Estimating time of death based on the biological clock

• DOI: 10.1007/s00414-010-0527-4
• 发表时间: 2011-05-01
• 期刊: INTERNATIONAL JOURNAL OF LEGAL MEDICINE
• 影响因子: 2.1
• 作者: Kimura, Akihiko;Ishida, Yuko;Kondo, Toshikazu
• 通讯作者: Kondo, Toshikazu

Pressure overload-induced cardiac hypertrophy affects oscillation amplitude of clock genes expression but not their circadian rhythm

压力超负荷引起的心脏肥大影响时钟基因表达的振荡幅度，但不影响其昼夜节律

• 发表时间: 2011
• 作者: 田頭秀章、Md.Shenuarin;Bhuiyan、塩田倫史、福永浩司;Kimura A
• 通讯作者: Kimura A