Investigation of the novel anti-angiogenesis therapy in an orthotopic implantation mouse model of human malignant pleural mesothelioma cells

人恶性胸膜间皮瘤细胞原位植入小鼠模型中新型抗血管生成疗法的研究

• 批准号: 22390166
• 负责人: SONE Saburo
• 金额: $ 11.07万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390166/
• 关键词: 非閉塞性肺疾患; 悪性胸膜中皮腫; 同所移植モデル; 血管新生; マイクロアレイ

The resistance against anti-VEGF therapy was investigated using orthotopic implantation mouse model of human malignant pleural mesothelioma cells. Although tumor angiogenesis was inhibited in the early phase ofanti-VEGF therapy, microvessel density was turned to increase in the late phase ofthe therapy, suggesting that the tumor acquired the resistance against anti-VEGF therapy. We found that the host FGF2 was up-regulated in the resistant tumor, and anti-FGFR therapy in combination with anti-VEGF therapy was more effective compared to anti-VEGF therapy alone. Angiogenic switch into different factors such as FGF2 seemed to play important role in the resistance against anti-VEGF therapy.

使用人恶性胸膜间皮瘤细胞的原位植入小鼠模型研究对抗VEGF治疗的抗性。虽然抗VEGF治疗早期肿瘤血管生成受到抑制，但治疗晚期肿瘤微血管密度增加，提示肿瘤获得了抗VEGF治疗的抵抗。我们发现宿主FGF2在耐药肿瘤中上调，与单独抗VEGF治疗相比，抗FGFR治疗与抗VEGF治疗联合使用更有效。血管生成因子如FGF2的转换在抗VEGF治疗的抵抗中起重要作用。

项目成果

難治性呼吸器疾患の治療法の開発を目指して.

旨在开发顽固性呼吸系统疾病的治疗方法。

• 发表时间: 2012
• 期刊: 呼吸
• 作者: Miyake K;Tani K;Kakiuchi S;Suzuka C;Toyoda Y;Kishi J;Tezuka T;Yuasa S;Hanibuchi M;Aono Y;Nishioka Y;Sone S;Kohno N;Yasuhiko Yamamoto;西岡安彦
• 通讯作者: 西岡安彦

Antitumor effects of anti-podoplanin antibody NZ-1 against malignant mesothelioma

抗平足蛋白抗体NZ-1对恶性间皮瘤的抗肿瘤作用

• 作者: Yasuhiko Nishioka;et al
• 通讯作者: et al

E7080 Suppresses Hematogenous Multiple Organ Metastases of Lung Cancer Cells with Nonmutated Epidermal Growth Factor Receptor

• DOI: 10.1158/1535-7163.mct-10-0707
• 发表时间: 2011-07-01
• 期刊: MOLECULAR CANCER THERAPEUTICS
• 影响因子: 5.7
• 作者: Ogino, Hirokazu;Hanibuchi, Masaki;Sone, Saburo
• 通讯作者: Sone, Saburo

Blockade of Th1 chemokine receptors ameliorates pulmonary granulomatosis in mice

• DOI: 10.1183/09031936.00070610
• 发表时间: 2011-08-01
• 期刊: EUROPEAN RESPIRATORY JOURNAL
• 影响因子: 24.3
• 作者: Kishi, J.;Nishioka, Y.;Sone, S.
• 通讯作者: Sone, S.

Dual Inhibition of Met Kinase and Angiogenesis to Overcome HGF-Induced EGFR-TKI Resistance in EGFR Mutant Lung Cancer

双重抑制 Met 激酶和血管生成，以克服 EGFR 突变型肺癌中 HGF 诱导的 EGFR-TKI 耐药性。

• DOI: 10.1016/j.ajpath.2012.05.023
• 发表时间: 2012-09-01
• 期刊: AMERICAN JOURNAL OF PATHOLOGY
• 影响因子: 6
• 作者: Takeuchi, Shinji;Wang, Wei;Yano, Seiji
• 通讯作者: Yano, Seiji