The regenerative therapy for central diabetes insipidus
The regenerative therapy for central diabetes insipidus
批准号:
22390188
负责人:
OISO Yutaka
金额:
$8.99万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
It is known mouse embryonic stem cell can be developed into hypothalamic lineage (ES-hypo) invitro. In this study, we have improved the method to have vasopressin neurons more effectively. Central diabetes insipidus manifests polyuria and polydipsia which results from the deficit in the hypothalamic area that produce vasopressin. We have developed a regenerativetherapy using ES-hypo in the model animal, Brattleboro rat. The heterograft of ES-hypo in the brain survived more than six weeks, and recipients reduced urine volume by 40% compared to the negative control group.
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Posttranscriptional regulation of vasopressin mRNA in a mouse model for familial neurohypophysial diabetes insipidus.
家族性神经垂体尿崩症小鼠模型中加压素 mRNA 的转录后调节。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[大磯ユタカ, 他]
通讯作者:
他
BiP mRNA expression is upregulated by dehydration in vasopressin neurons in the hypothalamus in mice
DOI:
10.1016/j.peptides.2011.12.011
发表时间:
2012-02-01
期刊:
PEPTIDES
影响因子:
3
作者:
[Hagiwara, Daisuke, Arima, Hiroshi, Oiso, Yutaka]
通讯作者:
Oiso, Yutaka
Protective Effect of Hedgehog Signaling on Cytokine-Induced Cytotoxicity in Pancreatic Beta-Cells.
Hedgehog 信号传导对胰腺 β 细胞细胞因子诱导的细胞毒性的保护作用。
DOI:
--
发表时间:
2010
期刊:
Experimental and Clinical Endocrinology & Diabetes
影响因子:
1.8
作者:
[大磯ユタカ, 他]
通讯作者:
他
DOI:
10.1097/wnr.0b013e3283556676
发表时间:
2012-08-01
期刊:
NEUROREPORT
影响因子:
1.7
作者:
[Ozawa, Yoshiharu, Arima, Hiroshi, Oiso, Yutaka]
通讯作者:
Oiso, Yutaka
DOI:
10.1016/j.regpep.2011.11.010
发表时间:
2012-02-10
期刊:
REGULATORY PEPTIDES
影响因子:
--
作者:
[Ito, Yoshihiro, Banno, Ryoichi, Oiso, Yutaka]
通讯作者:
Oiso, Yutaka
共 17 条
Analysis of process from ER stress to cell death in an animal model for disease
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批准号:23659475
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.25万
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财政年份:2011
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负责人:OISO Yutaka
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依托单位:
Analysis of neural cell death using knock-in mouse model and organotypic culture system.
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批准号:14370325
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.59万
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财政年份:2002
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负责人:OISO Yutaka
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依托单位:
Physiological characterization of the human vasopressin transgenic rats.
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批准号:08457263
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.8万
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财政年份:1996
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负责人:OISO Yutaka
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依托单位:
Genetic abnormalities of vasopressin gene and evaluation of gene expression.
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批准号:06671019
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1994
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负责人:OISO Yutaka
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依托单位:
Regulation and expression of vasopressin-neurophysin II gene.
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批准号:03671142
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1991
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负责人:OISO Yutaka
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依托单位:
Effects of Opioid Peptides on the Regulation of Vasopressin Secretion.
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批准号:01570633
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$0.9万
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财政年份:1989
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负责人:OISO Yutaka
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依托单位:
国内基金
海外基金
ERAD和Autophagy通路协同调控proAVP在内质网中质量控制的分子机理与中枢性尿崩症
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批准号:82070811
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项目类别:面上项目
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资助金额:58.0万元
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批准年份:2020
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负责人:石国军
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依托单位: