Attempt to induce tolerance of kidneys by pharmacologic rejuvenation of thymus in miniature swine

尝试通过药物使小型猪胸腺恢复活力来诱导肾脏耐受

• 批准号: 22390249
• 负责人: NOBORI Shuji
• 金额: $ 12.23万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390249/
• 关键词: 移植・再生医療; トランスレーショナルリサーチ; 胸腺; ミニブタ; 免疫寛容; 若年化再生; テストステロン; 制御性 T 細胞; 制御性T細胞; 腎移植; 移植免疫寛容

We have previously demonstrated that (1) thymus plays an important role in induction of transplant tolerance, and (2) extrinsic factors predominantly promote thymic rejuvenation in preclinical MHC inbred swine. Since considerable data in the swine model have indicated that the reason for this age dependence lies in the importance of a non-involuted, functional thymus during the induction period, the proposed study aimed to examine whether pharmacologically rejuvenated thymus induced by LH-RH agonist restored ability of inducing tolerance of allogeneic renal grafts in MHC inbred miniature swine.

我们以前已经证明，（1）胸腺在诱导移植耐受中起重要作用，（2）外在因素主要促进临床前MHC近交系猪的胸腺复壮。由于猪模型中的大量数据表明，这种年龄依赖性的原因在于诱导期内未退化的功能性胸腺的重要性，因此本研究旨在检查由LH-RH激动剂诱导的再生胸腺是否恢复MHC近交系小型猪同种异体肾移植耐受的诱导能力。

项目成果

Signal joint T-cell receptor excision circle assay in miniature swine.

• DOI: 10.1097/tp.0b013e31822b9287
• 发表时间: 2011-09-27
• 期刊: Transplantation
• 影响因子: 6.2
• 作者: Vallabhajosyula P;Tena A;Yamada K;Sachs DH
• 通讯作者: Sachs DH

The thymus is required to break tolerance of renal allografts in a miniature swine model

需要胸腺来打破小型猪模型中肾同种异体移植物的耐受性

• 发表时间: 2012
• 作者: Villani V;Yamada K et al
• 通讯作者: Yamada K et al

Kidney Transplantation - New Perspectives: Chapter 9: Mechanisms of Tolerance: Role of the Thymus and Persistence of Antigen in Calcineurin-Induced Tolerance of Renal Allografts in MGH Miniature Swine

肾移植 - 新视角：第 9 章：耐受机制：胸腺的作用和抗原持久性在钙调神经磷酸酶诱导 MGH 小型猪肾同种异体移植物耐受中的作用

• 发表时间: 2011
• 作者: Joseph R. Scalea;Isabel Hanekamp and Kazuhiko Yamada* (* 責任著者) InTech
• 通讯作者: Isabel Hanekamp and Kazuhiko Yamada* (* 責任著者) InTech

Reversal of age-related thymic involution by an LHRH agonist in miniature swine

• DOI: 10.1016/j.trim.2010.08.001
• 发表时间: 2010-10-01
• 期刊: TRANSPLANT IMMUNOLOGY
• 影响因子: 1.5
• 作者: Hirakata, Atsushi;Okumi, Masayoshi;Yamada, Kazuhiko
• 通讯作者: Yamada, Kazuhiko

Thymic transplantation in pig-to-nonhuman primates for the induction of tolerance across xenogeneic barriers.

• DOI: 10.1007/978-1-61779-845-0_12
• 发表时间: 2012-01-01
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Yamada, Kazuhiko;Scalea, Joseph
• 通讯作者: Scalea, Joseph