Attempt to induce tolerance of kidneys by pharmacologic rejuvenation of thymus in miniature swine

我们以前已经证明，（1）胸腺在诱导移植耐受中起重要作用，（2）外在因素主要促进临床前MHC近交系猪的胸腺复壮。由于猪模型中的大量数据表明，这种年龄依赖性的原因在于诱导期内未退化的功能性胸腺的重要性，因此本研究旨在检查由LH-RH激动剂诱导的再生胸腺是否恢复MHC近交系小型猪同种异体肾移植耐受的诱导能力。

We have previously demonstrated that (1) thymus plays an important role in induction of transplant tolerance, and (2) extrinsic factors predominantly promote thymic rejuvenation in preclinical MHC inbred swine. Since considerable data in the swine model have indicated that the reason for this age dependence lies in the importance of a non-involuted, functional thymus during the induction period, the proposed study aimed to examine whether pharmacologically rejuvenated thymus induced by LH-RH agonist restored ability of inducing tolerance of allogeneic renal grafts in MHC inbred miniature swine.