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Establishment of the purification and culture methods of human adipose-derived stem cells as an autogenous graft to ischemic brain tissue

Establishment of the purification and culture methods of human adipose-derived stem cells as an autogenous graft to ischemic brain tissue
人脂肪干细胞自体移植缺血脑组织的纯化及培养方法的建立
批准号:
22390274
负责人:
YOSHIMURA Shinichi
金额:
$9.24万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
In the present study, we tried to establish the methods of purification of human adipose-derived stem cells, and investigated to elucidate the neuroprotective effects and mechanisms of ADSCs againstacute cerebral ischemia. Administration of ADSCs had neuroprotective effects against experimental ischemic stroke and its therapeutic effects were mainly owing to neuroprotective and anti-inflammatory mechanisms of its secreting factors.
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DOI: 10.1016/j.neuroscience.2012.06.015
发表时间: 2012-09-18
期刊: NEUROSCIENCE
影响因子: 3.3
作者: [Ishiguro, M., Kawasaki, K., Hara, H.]
通讯作者: Hara, H.
マウス中大脳動脈虚血再灌流モデルに対するtPAとシロスタゾールの併用療法の検討
tPA与西洛他唑联合治疗小鼠大脑中动脉缺血再灌注模型的探讨
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [石黒光紀, 三代圭祐, 藤原泰之, 陳 華岳, 伊豆田洋志, 鶴間一寛, 嶋澤雅光, 吉村紳一. 佐藤雅彦, 岩間 亨, 原 英彰]
通讯作者: 原 英彰
DOI: 10.1038/hr.2010.58
发表时间: 2010-07-01
期刊: HYPERTENSION RESEARCH
影响因子: 5.4
作者: [Ikegame, Yuka, Yamashita, Kentaro, Iwama, Toru]
通讯作者: Iwama, Toru
2-Decenoic acid ethyl ester, a compound that elicits neurotrophin-like intracellular signals, facilitating functional recovery from cerebral nfarction in mice
2-癸烯酸乙酯,一种能引发神经营养蛋白样细胞内信号,促进小鼠脑梗塞功能恢复的化合物
DOI: --
发表时间: 2012
期刊: Int J Mol Sci
影响因子: 5.6
作者: [Tanaka Y, Fukumitsu H. Soumiya H Yoshimura S, Iwama T, Furukawa S]
通讯作者: Furukawa S
16
    Analysis of regulation mechanism of neurogenesis after traumatic brain injury and cerebral ischemia-roles of neurotrophic factors
    • 批准号:
      16390406
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $6.72万
    • 财政年份:
      2004
    • 负责人:
      YOSHIMURA Shinichi
    • 依托单位:
    Purification of lipid hydroperoxide reducing proteins from blood plasma, and analysis of its clinical roles
    • 批准号:
      10670146
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.05万
    • 财政年份:
      1998
    • 负责人:
      YOSHIMURA Shinichi
    • 依托单位:
    The human plasma glutathione peroxidase gene ; organization, nucleotide sequence and localization to chromosome 5q32.
    • 批准号:
      04670169
    • 项目类别:
      Grant-in-Aid for General Scientific Research (C)
    • 资助金额:
      $1.41万
    • 财政年份:
      1992
    • 负责人:
      YOSHIMURA Shinichi
    • 依托单位:
    海外基金