Development of an anti-aging protocol and maintaining undifferentiated state of oral mucosa keratinocyte progenitor/stem cells by pharmacological manipulation of autophagy

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The TOR-autophagy spatial coupling compartment (TASCC) represents for the intracytoplasmic region where protein degradation and synthesis occur in unison to handle rapid protein turnover by integration of rough endoplasmic reticulum, Golgi apparatus, (auto)lysosomes and mTOR, which is beneficial to cellsto efficiently produce secretory proteins. In this study, we found the TASCC in primary cultured human oral keratinocytes. In addition, our results suggested Maspin and IL-6 produced by oral keratinocyteswere synthesized and secreted through TASCC.