The role of interleukin-6 epigenetics in the pathogenesis of periodontitis and rheumatoid arthritis
The role of interleukin-6 epigenetics in the pathogenesis of periodontitis and rheumatoid arthritis
批准号:
22390396
负责人:
YOSHIE Hiromasa
金额:
$12.4万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
The aim of this study was to elucidate the role of interleukin-6 gene methylation in the pathogenesis of periodontitis and rheumatoid arthritis. The results indicated that the gene contained 19 methylation motifs, and hypomethylated status of a single motif was associated with two diseases. Additionally, methylation level was decreased in the gingival than those in blood, suggesting an increased level of IL-6 gene activity and inflammatory condition.
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歯周病原細菌に対する血清抗体価と関節リウマチとの関連
牙周病原菌血清抗体滴度与类风湿性关节炎的关系
DOI:
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发表时间:
2011
期刊:
影响因子:
--
作者:
[Aida J, Kondo K, Hirai H, Nakade M, Yamamoto T, Hanibuchi T, Osaka K, Sheiham A, Tsakos G, Watt RG, Hashizume,T.,kurita-Ochiai,T.,Yamamoto,M., 岡田萌]
通讯作者:
岡田萌
歯周炎罹患歯肉におけるIL-6遺伝子プロモーター領域のメチル化解析
牙周炎牙龈IL-6基因启动子区甲基化分析
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[芳賀秀郷, 山口徹太郎, 中岡博史, 山本健, 方山光朱, 木村亮介, 槇宏太郎, 井ノ上逸朗, 新谷誠康, 石田光平]
通讯作者:
石田光平
抗TNF療法による関節リウマチ患者の歯周組織状態の改善
抗TNF治疗改善类风湿关节炎患者牙周组织状况
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[東高志, 中井隆介, 渡邊誠, 茂野啓示, 小林哲夫]
通讯作者:
小林哲夫
Effects of periodontal therapy on the condition of rheumatoid arthritis
牙周治疗对类风湿性关节炎病情的影响
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Tsuboya T, Aida J, Kawachi I, Katase K, Osaka K., Marni E. Cueno, Okada M]
通讯作者:
Okada M
Effects of Anti-Tumor Necrosis Factor Therapy on Periodontal Condition in Patients with Rheumatoid Arthritis
抗肿瘤坏死因子治疗对类风湿性关节炎患者牙周状况的影响
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[木村亮介, 渡辺千晶, 山口徹太郎, 槇宏太郎, 武田麻耶子, 川口亮, 石田肇, Kobayashi T]
通讯作者:
Kobayashi T
共 19 条
An analysis of shared risk cytokine gene for periodontitis, diabetes mellitus, and rheumatoid arthritis
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批准号:25253104
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$28.79万
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财政年份:2013
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负责人:YOSHIE Hiromasa
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依托单位:
Establishment of the cytokine targeted therapy based on the pathogenesis of periodontitis
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批准号:24659922
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2012
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负责人:YOSHIE Hiromasa
-
依托单位:
Peroxisome proliferator-activated receptor gamma polymorphism andperiodontitis, preterm birth and obesity in pregnant Japanese women
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批准号:21659480
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.04万
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财政年份:2009
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负责人:YOSHIE Hiromasa
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依托单位:
RNA and protein expression based on risk gene polymorphisms in periodontitis and collagen diseases
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批准号:19390535
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.06万
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财政年份:2007
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负责人:YOSHIE Hiromasa
-
依托单位:
Bone homeostasis-related genes associated with susceptibility to periodicities
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批准号:13470461
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.56万
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财政年份:2001
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负责人:YOSHIE Hiromasa
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依托单位:
Fc receptor gene analysis and immunotherapy with bispecific antibody for periodontal disease
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批准号:12557191
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.59万
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财政年份:2000
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负责人:YOSHIE Hiromasa
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依托单位:
Identification of specific genes related to susceptibility to periodontitis
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批准号:10470457
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$8.45万
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财政年份:1998
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负责人:YOSHIE Hiromasa
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依托单位:
Molecular and genetic analysis of polymorphonuclear luekocytes in early onset periodontitis patients
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批准号:06454536
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.61万
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财政年份:1994
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负责人:YOSHIE Hiromasa
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依托单位:
Expression of collagenase and collagenase inhibitors mRNA in periodontitisaffected human gingival tissue.
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批准号:03454440
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.22万
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财政年份:1991
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负责人:YOSHIE Hiromasa
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依托单位:
Gingival lymphocyte functions in dog and human. I. Blastogenic responses to mitogens II. Antibody formation
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批准号:60570892
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.09万
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财政年份:1985
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负责人:YOSHIE Hiromasa
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依托单位:
海外基金