RNA and protein expression based on risk gene polymorphisms in periodontitis and collagen diseases
RNA and protein expression based on risk gene polymorphisms in periodontitis and collagen diseases
批准号:
19390535
负责人:
YOSHIE Hiromasa
金额:
$12.06万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
本研究では、歯周病と膠原病の感受性に関わる共通遺伝子を解明し、感受性に関連した歯肉組織中のRNA発現と好中球におけるタンパクを同定することを目的とした。解析の結果、歯周炎・膠原病患者のFc受容体、インターロイキン1,6の関連が明確となり、また好中球産生タンパクとしてシトルリン化変換酵素タンパクの発現亢進、さらに歯周炎歯肉組織での共通変動遺伝子発現が同定された。
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Differential gene and protein expression of tissue inhibitors of metalloproteinase(TIMP)-3 and TIMP-4 in gingival tissues from drug induced gingival overgrowth
药物性牙龈过度生长牙龈组织中金属蛋白酶组织抑制剂(TIMP)-3和TIMP-4基因和蛋白的差异表达
DOI:
--
发表时间:
2009
期刊:
Archives of Oral Biology 54(7)
影响因子:
--
作者:
[Tsutsumi A, Kobayashi T, Ito S, Goto D, Matsumoto I, Yoshie H, Sumida T, Naohiro Nakasone]
通讯作者:
Naohiro Nakasone
An analysis of shared risk cytokine gene for periodontitis, diabetes mellitus, and rheumatoid arthritis
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批准号:25253104
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$28.79万
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财政年份:2013
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负责人:YOSHIE Hiromasa
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依托单位:
Establishment of the cytokine targeted therapy based on the pathogenesis of periodontitis
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批准号:24659922
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2012
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负责人:YOSHIE Hiromasa
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依托单位:
The role of interleukin-6 epigenetics in the pathogenesis of periodontitis and rheumatoid arthritis
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批准号:22390396
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.4万
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财政年份:2010
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负责人:YOSHIE Hiromasa
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依托单位:
Peroxisome proliferator-activated receptor gamma polymorphism andperiodontitis, preterm birth and obesity in pregnant Japanese women
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批准号:21659480
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.04万
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财政年份:2009
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负责人:YOSHIE Hiromasa
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依托单位:
Bone homeostasis-related genes associated with susceptibility to periodicities
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批准号:13470461
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.56万
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财政年份:2001
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负责人:YOSHIE Hiromasa
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依托单位:
Fc receptor gene analysis and immunotherapy with bispecific antibody for periodontal disease
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批准号:12557191
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.59万
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财政年份:2000
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负责人:YOSHIE Hiromasa
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依托单位:
Identification of specific genes related to susceptibility to periodontitis
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批准号:10470457
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$8.45万
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财政年份:1998
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负责人:YOSHIE Hiromasa
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依托单位:
Molecular and genetic analysis of polymorphonuclear luekocytes in early onset periodontitis patients
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批准号:06454536
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.61万
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财政年份:1994
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负责人:YOSHIE Hiromasa
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依托单位:
Expression of collagenase and collagenase inhibitors mRNA in periodontitisaffected human gingival tissue.
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批准号:03454440
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.22万
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财政年份:1991
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负责人:YOSHIE Hiromasa
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依托单位:
Gingival lymphocyte functions in dog and human. I. Blastogenic responses to mitogens II. Antibody formation
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批准号:60570892
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.09万
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财政年份:1985
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负责人:YOSHIE Hiromasa
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依托单位:
海外基金