RNA and protein expression based on risk gene polymorphisms in periodontitis and collagen diseases

基于牙周炎和胶原病风险基因多态性的RNA和蛋白质表达

• 批准号: 19390535
• 负责人: YOSHIE Hiromasa
• 金额: $ 12.06万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390535/
• 关键词: 歯周炎; 膠原病; リスク遺伝子; RNA発現; プロテオーム; 歯学; 遺伝子; 蛋白質

本研究では、歯周病と膠原病の感受性に関わる共通遺伝子を解明し、感受性に関連した歯肉組織中のRNA発現と好中球におけるタンパクを同定することを目的とした。解析の結果、歯周炎・膠原病患者のFc受容体、インターロイキン1,6の関連が明確となり、また好中球産生タンパクとしてシトルリン化変換酵素タンパクの発現亢進、さらに歯周炎歯肉組織での共通変動遺伝子発現が同定された。

In this study, we found that there was a common understanding of the RNA in the tissue of the primary disease, the disease of the disease, the susceptibility of the disease, the sensitivity of the disease and the sensitivity of the disease. The results showed that the Fc receptor of the patients with periodontitis was significantly higher than that of the patients with periodontitis, and the results showed that the Fc receptor of the patients with periodontitis was higher than that of the patients with periodontitis.

项目成果

Differential gene and protein expression of tissue inhibitors of metalloproteinase(TIMP)-3 and TIMP-4 in gingival tissues from drug induced gingival overgrowth

药物性牙龈过度生长牙龈组织中金属蛋白酶组织抑制剂(TIMP)-3和TIMP-4基因和蛋白的差异表达

• 发表时间: 2009
• 期刊: Archives of Oral Biology 54(7)
• 作者: Tsutsumi A;Kobayashi T;Ito S;Goto D;Matsumoto I;Yoshie H;Sumida T;Naohiro Nakasone
• 通讯作者: Naohiro Nakasone