Peroxisome proliferator-activated receptor gamma polymorphism andperiodontitis, preterm birth and obesity in pregnant Japanese women

过氧化物酶体增殖物激活受体γ多态性与日本孕妇牙周炎、早产和肥胖

• 批准号: 21659480
• 负责人: YOSHIE Hiromasa
• 金额: $ 2.04万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21659480/
• 关键词: 歯周病; 産科学; ゲノム; 遺伝子型; 肥満; PPAR; 早産; 核内レセプター

PPAR gamma is a nuclear hormone receptor which regulates lipid metabolism and production of inflammatory cytokines. A functional genetic polymorphism Pro12Ala has been reported. Recent studies have suggested an association between periodontitis and preterm birth or obesity. We investigated relationships between PPAR gamma polymorphism, periodontitis, preterm birth and obesity in pregnant Japanese women. There was no significant association between periodontitis and preterm birth, or between periodontitis and obesity. However, a significant association of the polymorphism and periodontitis was found in the Japanese pregnant women.

PPAR γ是一种核激素受体，调节脂质代谢和炎症细胞因子的产生。已报道了一种功能性遗传多态性Pro12Ala。最近的研究表明牙周炎和早产或肥胖之间存在联系。我们调查了日本孕妇中过氧化物酶体增殖物激活受体γ多态性、牙周炎、早产和肥胖之间的关系。牙周炎与早产、牙周炎与肥胖之间无显著相关性。然而，一个显着的关联的多态性和牙周炎被发现在日本孕妇。

项目成果

FcyRIIB polymorphisms, periodontitis and preterm birth in Japanese pregnant women.

日本孕妇的 FcyRIIB 多态性、牙周炎和早产。

• 发表时间: 2011
• 期刊: Journal of Periodontal Research
• 影响因子: 3.5
• 作者: Masahiro Saito;et al;Ruriko Iwanaga
• 通讯作者: Ruriko Iwanaga

Peroxisome proliferator-activated receptor gamma polymorphism and periodontitis in pregnant Japanese women

日本孕妇过氧化物酶体增殖物激活受体γ多态性与牙周炎

• 发表时间: 2010
• 期刊: Journal of Periodontology
• 影响因子: 4.3
• 作者: Hirano E;Sugita N(2番目);Kikuchi A(3番目);Yoshie H(8番目);他4名
• 通讯作者: 他4名

Infection with Aggregatibacter actinomycetemcomitans and adverse pregnancy outcoms.

伴放线聚合杆菌感染和不良妊娠结局。

• 发表时间: 2010
• 作者: 道脇幸博;安藤亮一;Emi Hirano
• 通讯作者: Emi Hirano

FcγRIIB-nt645+25A? G gene polymorphism and periodontitis in Japanese women with preeclampsia

FcγRIIB-nt645+25A?G基因多态性与日本子痫前期女性牙周炎

• DOI: 10.1111/j.1744-313x.2012.01124.x
• 发表时间: 2012
• 期刊: International Journal of Immunogenetics
• 影响因子: 2.2
• 作者: Wang Y;Sugita N(2番目);Kikuchi A(3番目);Yoshie H(9番目);他5名
• 通讯作者: 他5名

FcγRIIB polymorphisms associated with periodontits and preterm birth

FcγRIIB 多态性与牙周病和早产相关

• 发表时间: 2010
• 作者: Iwanaga R;Sugita N(2番目);Kikuchi A(5番目);Yoshie H(7番目);他3名
• 通讯作者: 他3名