A fundamental research on a new AIDS treatment based on an error rate control of HIV-1 reverse transcriptase

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The present project aims to establish theoretical bases on an alternative AIDS treatment for ART, which simultaneously administers multiple anti-HIV drugs to an AIDS patient. It is well known that HIV-1 is frequently-mutated. The alternative AIDS treatment is by inducing excess mutations to HIV-1 RNA(+) genome, to drive HIV-1 quasi-species population to self-destruction. Namely it uses the HIV-1error-prone character as an underhanded way. This project proposes a novel HIV-1 mathematical model considered viral kinetic processes such as mutation, replication, infection and mutagenic activities to control HIV-1 mutation rate. Numerical simulations of the model show that enhancement of a HIV-1 mutation rate causes an “error catastrophe”to HIV-1 quasi-species population. Furthermore, analyses of local asymptotic stability of the self-destruction state reveal that the alternative AIDS treatment haseffectiveness under certain specific viral conditions.