Identification of new predictive factors for chemo-radiation against oral cancers and setting of individualized medicine based on their expressions
Identification of new predictive factors for chemo-radiation against oral cancers and setting of individualized medicine based on their expressions
批准号:
21592555
负责人:
HARADA Koji
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
点击翻译按钮获取中文摘要
英文摘要
We established anticancer drug-resistant or radiation-resistant oral cancer cell lines. The specific fluctuating genes between a 5-FU-resistant cell line and a non 5-FU-resistant cell line were identified through microarray analysis, and we identified candidate genes including GDF15. We found a trifluorothymidine by investigating the agent can suppress the candidate gene expression. These finding suggested that trifluorothymidine based chemotherapy may be one of options for recurrent cases after 5-FU based chemotherapy.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Migration-stimulating factor as a novel biomarker in salivary gland tumours
迁移刺激因子作为唾液腺肿瘤的新型生物标志物
DOI:
--
发表时间:
2011
期刊:
J Oral Pathol Med
影响因子:
3.3
作者:
[Aljorani LE, Bankfalvi A, Carey FA, Harada K, Ohe G, Jones SJ, Ellis IR, Schor SL, Schor AM., 銅前昇平, Aljorani LE]
通讯作者:
Aljorani LE
Comparison of apatite-coated titanium prepared by blast coating and flame spray methods-Evaluation using simulated body fluid and initial histological study
喷砂和火焰喷涂方法制备的磷灰石涂层钛的比较-使用模拟体液进行评估和初步组织学研究
DOI:
--
发表时间:
2011
期刊:
Dental Materials Journal
影响因子:
2.5
作者:
[Mano T, Ishikawa K, Harada K, Uchida H, Ueyama Y]
通讯作者:
Ueyama Y
口腔癌に対するフッ化ピリミジン系経口抗癌剤を用いた新たな治療戦略
氟嘧啶类口服抗癌药治疗口腔癌的新策略
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Odan N, Fujikawa K, Toyoda J, Hasegawa O, Abukawa H, Watanabe M, Satomi T, Kaneko T, Matsuo A, Chikazu D, 原田耕志]
通讯作者:
原田耕志
Cepharanthine enhances radiosensitivity through the inhibition of DNA double-strand break repair in oral cancer cells.
Cepharanthine 通过抑制口腔癌细胞中 DNA 双链断裂修复来增强放射敏感性。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Muraki C., Hida Y., Totsuka Y., Shindoh M., Hida K., Koji Harada]
通讯作者:
Koji Harada
口扁平上皮癌に対する経口抗癌剤TS-1を用いたメトロノミックケモテラピーの有用性とそのメカニズムの解析
口服抗癌药TS-1节律化疗治疗口腔鳞癌的有效性及机制分析
DOI:
--
发表时间:
2011
期刊:
学術の森
影响因子:
--
作者:
[Morishima N, Mizoguchi I, Takeda K, Mizuguchi J, Yoshimoto T, 原田耕志]
通讯作者:
原田耕志
共 11 条
Development of novel treatment against refractory oral cancer by uptake inhibition of iron or induction of ferroptosis
-
批准号:18K09814
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.75万
-
财政年份:2018
-
负责人:HARADA Koji
-
依托单位:
Development of new oral cancer treatments focused on mTOR inhibition leading to the anti-aging prevention and the healthy life-span extension
-
批准号:15K11292
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.08万
-
财政年份:2015
-
负责人:HARADA Koji
-
依托单位:
Development of a novel functional preservation therapy against advanced, recurrent or unresectable oral cancers.
-
批准号:24593034
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.41万
-
财政年份:2012
-
负责人:HARADA Koji
-
依托单位:
Examination of the physical pictures of the field theories with nonlinearly realized symmetries by the Wilsonian renormalization group method
-
批准号:22540286
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.83万
-
财政年份:2010
-
负责人:HARADA Koji
-
依托单位:
A fundamental research on a new AIDS treatment based on an error rate control of HIV-1 reverse transcriptase
-
批准号:22500273
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.08万
-
财政年份:2010
-
负责人:HARADA Koji
-
依托单位:
Development of the therapy for oral cancer by S-1 and proteasome inhibitor in combination with concurrent radiotherapy
-
批准号:19592339
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2007
-
负责人:HARADA Koji
-
依托单位:
Understanding a mechanism of HIV-1 drug resistance development under the RTI pressure and the development of a medication scheduling system
-
批准号:18700293
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$1.72万
-
财政年份:2006
-
负责人:HARADA Koji
-
依托单位:
Development of molecular targeting therapy against stability of p27^<Kip1> protein in oral squamous cell carcinoma.
-
批准号:17592089
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2005
-
负责人:HARADA Koji
-
依托单位:
Development of molecular targeting therapy against p27^<Kip1> in oral squamous cell carcinoma.
-
批准号:15592116
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2003
-
负责人:HARADA Koji
-
依托单位:
Relationship between p27^<Kip1> expression and tumor differention and prognosis in human oral squamous cell carcinoma.
-
批准号:11671990
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$0.45万
-
财政年份:1999
-
负责人:HARADA Koji
-
依托单位:
海外基金