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Identification of new predictive factors for chemo-radiation against oral cancers and setting of individualized medicine based on their expressions

Identification of new predictive factors for chemo-radiation against oral cancers and setting of individualized medicine based on their expressions
口腔癌放化疗新预测因素的鉴定以及基于其表达的个体化医疗设置
批准号:
21592555
负责人:
HARADA Koji
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
We established anticancer drug-resistant or radiation-resistant oral cancer cell lines. The specific fluctuating genes between a 5-FU-resistant cell line and a non 5-FU-resistant cell line were identified through microarray analysis, and we identified candidate genes including GDF15. We found a trifluorothymidine by investigating the agent can suppress the candidate gene expression. These finding suggested that trifluorothymidine based chemotherapy may be one of options for recurrent cases after 5-FU based chemotherapy.
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会议论文
Migration-stimulating factor as a novel biomarker in salivary gland tumours
迁移刺激因子作为唾液腺肿瘤的新型生物标志物
DOI: --
发表时间: 2011
期刊: J Oral Pathol Med
影响因子: 3.3
作者: [Aljorani LE, Bankfalvi A, Carey FA, Harada K, Ohe G, Jones SJ, Ellis IR, Schor SL, Schor AM., 銅前昇平, Aljorani LE]
通讯作者: Aljorani LE
Comparison of apatite-coated titanium prepared by blast coating and flame spray methods-Evaluation using simulated body fluid and initial histological study
喷砂和火焰喷涂方法制备的磷灰石涂层钛的比较-使用模拟体液进行评估和初步组织学研究
DOI: --
发表时间: 2011
期刊: Dental Materials Journal
影响因子: 2.5
作者: [Mano T, Ishikawa K, Harada K, Uchida H, Ueyama Y]
通讯作者: Ueyama Y
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Odan N, Fujikawa K, Toyoda J, Hasegawa O, Abukawa H, Watanabe M, Satomi T, Kaneko T, Matsuo A, Chikazu D, 原田耕志]
通讯作者: 原田耕志
Cepharanthine enhances radiosensitivity through the inhibition of DNA double-strand break repair in oral cancer cells.
Cepharanthine 通过抑制口腔癌细胞中 DNA 双链断裂修复来增强放射敏感性。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Muraki C., Hida Y., Totsuka Y., Shindoh M., Hida K., Koji Harada]
通讯作者: Koji Harada
11
    Development of novel treatment against refractory oral cancer by uptake inhibition of iron or induction of ferroptosis
    • 批准号:
      18K09814
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.75万
    • 财政年份:
      2018
    • 负责人:
      HARADA Koji
    • 依托单位:
    Development of new oral cancer treatments focused on mTOR inhibition leading to the anti-aging prevention and the healthy life-span extension
    • 批准号:
      15K11292
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.08万
    • 财政年份:
      2015
    • 负责人:
      HARADA Koji
    • 依托单位:
    Development of a novel functional preservation therapy against advanced, recurrent or unresectable oral cancers.
    • 批准号:
      24593034
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.41万
    • 财政年份:
      2012
    • 负责人:
      HARADA Koji
    • 依托单位:
    Examination of the physical pictures of the field theories with nonlinearly realized symmetries by the Wilsonian renormalization group method
    • 批准号:
      22540286
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.83万
    • 财政年份:
      2010
    • 负责人:
      HARADA Koji
    • 依托单位:
    海外基金