Development of the therapy for oral cancer by S-1 and proteasome inhibitor in combination with concurrent radiotherapy

S-1和蛋白酶体抑制剂联合同步放疗治疗口腔癌的进展

• 批准号: 19592339
• 负责人: HARADA Koji
• 金额: $ 2.91万
• 依托单位: Yamaguchi University (2008)The University of Tokushima (2007)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19592339/
• 关键词: プロテアソーム阻害剤; 5-FU; TS-1; 放射線; 併用療法; NF-κB; アポトーシス、オートファジー; NF-KB; 口腔癌

プロテアソーム阻害剤1(PSI1)は口腔扁平上皮癌細胞に対して、単剤で細胞増殖抑制効果を示し、5-FUおよび放射線(RT)との3者併用処理にて強い細胞増殖抑制効果が見られた。ヌードマウス腫瘍に対してもPSI1は単剤で抗腫瘍効果を示し、TS-1およびRTとの3者併用では顕著な抗腫瘍効果を示した。なおin vitroにおいてPSI1は口腔扁平上皮癌細胞のNF-κB活性を有意に抑制し、PSI1と5-FUはともにRTで活性化された口腔扁平上皮癌細胞のNF-κB活性を抑制した。

Cell proliferation inhibition of oral flat epithelial carcinoma (PSI1), cell proliferation inhibition of oral flat epithelial carcinoma and 5-FU radiation radiation (RT) were used in this study. In the case of PSI1, the results of resistance were indicated, while those of TS-1, RT, and others showed the results of resistance. The activity of NF- kappa B in oral squamous cell carcinoma was suppressed intentionally, the activity of NF- kappa B was suppressed intentionally in oral squamous cell carcinoma, and the activity of NF- kappa B was suppressed in oral squamous cell carcinoma. The activity of NF- kappa B was intentionally suppressed, and the activity of NF- kappa B was suppressed in oral squamous cell carcinoma.

项目成果

Multi-institutional phase II trial of S-1 in patients with oral squamous cell carcinoma

• DOI: 10.1097/cad.0b013e3282f0ce4d
• 发表时间: 2008-01-01
• 期刊: ANTI-CANCER DRUGS
• 影响因子: 2.3
• 作者: Harada, Koji;Sato, Mitsunobu;Ryoke, Kazuo
• 通讯作者: Ryoke, Kazuo