Analysis of molecular integration by basal membrane in synapse formation and maintenance.
Analysis of molecular integration by basal membrane in synapse formation and maintenance.
批准号:
22500356
负责人:
HOSOKAWA Hiroshi
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
A physiological roles of molecular integration in synapse was studied by analysis of MAGI1 which indirectly binds to basal membrane. Biochemical and histochemical analysis revealed that MAGI1 was expressed in neuronal cells and localized on post synapse in brain. MAGI1 knockout mice showed abnormal anxiety -like and attention behaviour. In conlusion, molecular integration was required for normal synapse function and behavior.
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DOI:
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发表时间:
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期刊:
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DOI:
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DOI:
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发表时间:
2011-06-01
期刊:
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影响因子:
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海外基金