Eicosapentaenoic acid supplementation on baroreflex sensitivity in patients with coronary artery disease.

补充二十碳五烯酸对冠状动脉疾病患者压力反射敏感性的影响。

• 批准号: 22500668
• 负责人: YUFU Kunio
• 金额: $ 1.33万
• 依托单位: Oita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22500668/
• 关键词: 心臓自律神経; 魚油; baroreflex sensitivity; Eicosapentaenoic acid; 心血管イベント; MACE; 自律神経; N-3 Polyunsaturated Fatty Acids; Heart Rate Variability; autonomic function; 性差; 2型糖尿病; maior adverse cardiac and cerebrovascular events; 自律神経機能

(1)BRS value could predict cardio- and cerebrovascular events in patients with type 2 diabetes. Therapeutic preventive strategies targeting the improvement of BRS should be considered in this population. (2)Depressed BRS value could predict cardiac cerebrovascular events especially in female patients with type 2 diabetes. Once diabetic, a female who developed an impaired BRS had a worse prognosis than similar male. Intensive management and/or therapy might be needed in this population. (3)Dietary EPA supplementation might increase serum levels of EPA and BRS value in patients with coronary artery disease. These effects might be one of reason why EPA had been associated with a reduced incidence of adverse cardiovascular events in patients with coronary artery disease.

（1）BRS值可预测2型糖尿病患者的心脑血管事件。应考虑在这一人群中采取针对改善BRS的治疗性预防策略。（2）BRS值降低可预测心脑血管事件，尤其是女性2型糖尿病患者。一旦患上糖尿病，出现BRS受损的女性的预后比相似的男性更差。这一人群可能需要强化管理和/或治疗。（3）补充EPA可提高冠心病患者血清EPA水平和BRS值。这些作用可能是EPA降低冠心病患者不良心血管事件发生率的原因之一。

项目成果

心臓自律神経の2型糖尿病患者における脳心血管イベントの予測～性差について～

心脏自主神经系统对2型糖尿病患者脑心事件的预测-关于性别差异-

• 发表时间: 2012
• 作者: Megumi Kubota;Hirotoshi Shimizu;油布邦夫
• 通讯作者: 油布邦夫

Gender difference in baroreflex sensitivity to predict cardiac and cerebrovascular events in type 2 diabetic patients.

预测 2 型糖尿病患者心脑血管事件的压力反射敏感性的性别差异。

• DOI: 10.1253/circj.cj-10-1122
• 发表时间: 2011
• 期刊: Circulation journal : official journal of the Japanese Circulation Society
• 作者: K. Yufu;N. Takahashi;Norihiro Okada;O. Wakisaka;T. Shinohara;M. Nakagawa;M. Hara;H. Yoshimatsu;T. Saikawa
• 通讯作者: T. Saikawa

Tetsunori Saikawa.Eicosapentaenoic acid supplementation on baroreflex sensitivity in patients with coronary artery disease

Tetsunori Saikawa.补充二十碳五烯酸对冠状动脉疾病患者压力反射敏感性的影响

• 发表时间: 2013
• 作者: Norihiro Okada;Naohiko Takahashi;Yuki Ebata;Tetsuji Shinohara;Kunio Yufu;Mikiko Nakagawa;Masahide Hara
• 通讯作者: Masahide Hara

Eicosapentaenoic acid supplementation on baroreflex sensitivity in patients with coronary artery disease.

补充二十碳五烯酸对冠状动脉疾病患者压力反射敏感性的影响。

• 发表时间: 2013
• 作者: Norihiro Okada;Naohiko Takahashi;Yuki Ebata;Tetsuji Shinohara;Kunio Yufu;Mikiko Nakagawa;Masahide Hara;崎間敦;Norihiro Okada
• 通讯作者: Norihiro Okada

糖尿病と心臓自律神経障害

糖尿病和心脏自主神经病变

• 发表时间: 2013
• 期刊: 月刊糖尿病 糖尿病と心疾患 -基礎と臨床-
• 作者: 等々力英美;崎間敦;油布邦夫
• 通讯作者: 油布邦夫