Eicosapentaenoic acid supplementation on baroreflex sensitivity in patients with coronary artery disease.

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(1)BRS value could predict cardio- and cerebrovascular events in patients with type 2 diabetes. Therapeutic preventive strategies targeting the improvement of BRS should be considered in this population. (2)Depressed BRS value could predict cardiac cerebrovascular events especially in female patients with type 2 diabetes. Once diabetic, a female who developed an impaired BRS had a worse prognosis than similar male. Intensive management and/or therapy might be needed in this population. (3)Dietary EPA supplementation might increase serum levels of EPA and BRS value in patients with coronary artery disease. These effects might be one of reason why EPA had been associated with a reduced incidence of adverse cardiovascular events in patients with coronary artery disease.