EXPERIMENTAL STUDIES ON MECHANISMS OF HEPATIC LOBULE FORMATION USING MUTANT MICE LACKING C/EBPα

点击翻译按钮获取中文摘要

The present study was undertaken to demonstrate novel cell-cell interactions of liver lobule formation using C/EBPα-knockout mice, in which hepatocyte maturation was severely impaired. In the knockout liver, abnormal bile duct formation, activation of hepatic stellate cells and immature sinusoidal endothelial cells were noted, suggesting that hepatocytes intimately interact with biliary cells, hepatic stellate cells and sinusoidal endothelial cells to develop liver lobules. Growth factors such as PDGFC and angiopoietin-like 3 could be involved in these phenomena.