Mosaic analysis of cell lineages in mouse liver

目前的研究用spfy-D1 ashy-D1-不同女性小鼠分析了肝脏和小直觉中的细胞线条，并引导到后续的整合：1。不同个体中的变形模式并不与个体解剖学（如个体小册子）有关。本结果建议，即不能直接从门户区域迁移到中心区域。Hepatocytes分配他们的女儿细胞随机和相干。在他们的细胞线上有三种类型的Hepatoblasts：Hepatoblasts赋予只成熟Hepatocytes， Hepatoblasts赋予只双表皮细胞，以及Hepatoblasts赋予两个细胞。在新生期开始的小密码形成中，但不成熟的密码不是单克隆的。在2个星期的时间里，单克隆密码被证实了。胎儿肝脏中的补丁和小直觉非常小，建议将扩展的细胞混合和迁移置于这些周期的位置。

The present study with the spfィイD1ashィエD1-heterozygous female mouse analyzed the cell lineages in the liver and small intestine, and leads to the following conclusions:1. The mosaic pattern in the heterozygous liver is not related to the liver anatomy such as the liver lobule. This result suggests that hepatocytes do not migrate straight from the portal area to central area. Hepatocytes allocate their daughter cells randomly and coherently.2. There are three types of hepatoblasts in their cell lineages: hepatoblasts giving rise to only mature hepatocytes, hepatoblasts giving rise to only biliary epithelial cells, and hepatoblasts giving rise to both cells.3. The crypt formation in the small intestine starts at the neonatal period, but the immature crypt was not monoclonal. The monoclonal crypts were established in 2-weeks-old small intestine.4. Patches in fetal liver and small intestine were very small, suggesting that extensive cell mixing and migration take place at these periods.