Mosaic analysis of cell lineages in mouse liver

The present study with The spf - 1-heterozygous female mouse analyzed The cell lineages inthe liver and small intestine并leads to the following conclusions:1. mosaic pattern in the heterozygous liver is not the mosaic pattern相关的liver anatomy such as the liver lobule. This result suggests that hepatocytes do notmigrate straight from the portal area to central area. Hepatocytes allocate their daughter cellsrandomly and coherently.2. There are三个类型的hepatoblasts in their cell lineages：hepatoblasts to only mature hepatocyteshepatoblasts giving rise to only biliary epithelial cells与hepatoblasts giving rise to both cells.3. crypt formation in The small intestine starts atthe neonatal periodmonoclonal crypts were established in 2-week -old4. Patches in fetal liver and small intestine were very small，suggesting extensive cell mixing and migration take place at these periods。

The present study with the spfィイD1ashィエD1-heterozygous female mouse analyzed the cell lineages in the liver and small intestine, and leads to the following conclusions:1. The mosaic pattern in the heterozygous liver is not related to the liver anatomy such as the liver lobule. This result suggests that hepatocytes do not migrate straight from the portal area to central area. Hepatocytes allocate their daughter cells randomly and coherently.2. There are three types of hepatoblasts in their cell lineages: hepatoblasts giving rise to only mature hepatocytes, hepatoblasts giving rise to only biliary epithelial cells, and hepatoblasts giving rise to both cells.3. The crypt formation in the small intestine starts at the neonatal period, but the immature crypt was not monoclonal. The monoclonal crypts were established in 2-weeks-old small intestine.4. Patches in fetal liver and small intestine were very small, suggesting that extensive cell mixing and migration take place at these periods.