Glucose transport pathways in the cochlear stria vascularis

本研究提供了第一个证据表明，八个GLUT亚型的mRNA表达的血管纹和螺旋韧带。这些GLUT亚型被怀疑参与血管纹的高代谢活动，并在维持耳蜗葡萄糖稳态中发挥特定作用。在这些异构体中，GLUT 1、-4和-10蛋白在基底细胞中表达。这些发现证实了葡萄糖通过基底细胞层从外淋巴液到脑内空间的跨细胞途径。我们还证明了GLUT 13（HMIT）在耳蜗边缘细胞中表达，并推测边缘细胞中的HMIT可能参与PI合成、耳蜗液的pH调节和pH稳态。

The present study provides the first evidence that mRNAs of eight GLUT isoforms are expressed in the stria vascularis and the spiral ligament. These GLUT isoforms are suspected to involve in the high metabolic activity of the stria vascularis, and to play specific roles in maintenance of cochlear glucose homeostasis. Among these isoforms, GLUT1, -4 and -10 proteins were expressed in the strial basal cells. These findingsvalidate the transcellular glucose pathway from perilymph to intrastrial space via the basal cell layer. We also demonstrated that GLUT13 (HMIT) was expressed in the strial marginal cells, and speculate that HMIT in the marginal cells may be involved in PI synthesis, osmoregulation, and pH homeostasis of cochlear fluids.