Glucose transport pathways in the cochlear stria vascularis

本研究首次提供了八种GLUT亚型的mRNAs在血管纹和螺旋韧带中表达的证据。这些GLUT异构体被怀疑参与了血管纹的高代谢活动，并在维持耳蜗糖稳态方面发挥了特定的作用。在这些异构体中，GLUT1、-4和-10蛋白在纹状体基底层细胞中表达。这些发现证实了跨细胞葡萄糖途径从外淋巴液通过基底细胞层进入内腔。我们还证实了GLUT13(HMIT)在边缘细胞中的表达，推测边缘细胞中的HMIT可能参与了耳蜗液的PI合成、渗透调节和pH动态平衡。

The present study provides the first evidence that mRNAs of eight GLUT isoforms are expressed in the stria vascularis and the spiral ligament. These GLUT isoforms are suspected to involve in the high metabolic activity of the stria vascularis, and to play specific roles in maintenance of cochlear glucose homeostasis. Among these isoforms, GLUT1, -4 and -10 proteins were expressed in the strial basal cells. These findingsvalidate the transcellular glucose pathway from perilymph to intrastrial space via the basal cell layer. We also demonstrated that GLUT13 (HMIT) was expressed in the strial marginal cells, and speculate that HMIT in the marginal cells may be involved in PI synthesis, osmoregulation, and pH homeostasis of cochlear fluids.