Glucose transport pathways in the cochlear stria vascularis

本研究首次证实了8种GLUT亚型的mrna在血管纹和螺旋韧带中表达。这些GLUT亚型被怀疑参与血管纹的高代谢活动，并在维持耳蜗葡萄糖稳态中发挥特定作用。在这些亚型中，GLUT1、-4和-10蛋白在基底细胞中表达。这些发现证实了从淋巴管周围经基底细胞层进入胃内的细胞间葡萄糖通路。我们还证实GLUT13 （HMIT）在耳蜗边缘细胞中表达，并推测边缘细胞中的HMIT可能参与耳蜗液的PI合成、渗透调节和pH稳态。

The present study provides the first evidence that mRNAs of eight GLUT isoforms are expressed in the stria vascularis and the spiral ligament. These GLUT isoforms are suspected to involve in the high metabolic activity of the stria vascularis, and to play specific roles in maintenance of cochlear glucose homeostasis. Among these isoforms, GLUT1, -4 and -10 proteins were expressed in the strial basal cells. These findingsvalidate the transcellular glucose pathway from perilymph to intrastrial space via the basal cell layer. We also demonstrated that GLUT13 (HMIT) was expressed in the strial marginal cells, and speculate that HMIT in the marginal cells may be involved in PI synthesis, osmoregulation, and pH homeostasis of cochlear fluids.