Characterization of a novel protein which inhibits adipocytes differentiation

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Two kinds of adipose tissues are known to exist in mammals; white and brown adipose tissue. The physiological role of white adipose tissue is storage of bioenergy in the form of fat. Unlike white adipose tissue, the role of brown adipose tissue is dissipation of energy as heat, which prevents mammals from excess storage of energy. We obtained a cDNA encoding a novel protein which abundantly expressed in brown adipose tissue. The putative SH3 domain located on the C-terminal region of this protein can bind dynamin, and it is suggested that the binding of this protein to dynamininhibits endocytosis process. When this protein was overexpressed in preadipocytes, differentiation to mature adipocytes was inhibited. These results suggest that a novel protein abundantly expressed in brown adipose tissue regulates dynamin-mediated endocytosis and its overexpression inhibits adipocytes differentiation.