Regulation of hippocampal neurogenesis by the amygdala

杏仁核对海马神经发生的调节

• 批准号: 22590089
• 负责人: ABE Kazuho
• 金额: $ 2.58万
• 依托单位: Musashino University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590089/
• 关键词: 海馬; 神経新生; 扁桃体; アルツハイマー病; 神経幹細胞

The present study investigated whether the amygdala plays a role in regulation of neurogenesis in the hippocampus. Transection of the fimbria-fornix in the rat resulted in an increase of the number of neural stem cells (bromodeoxyuridine-positive cells) in the dentate gyrus. Lesion of the amygdala in the rat resulted in a decrease of the number of neural stem cells in the dentate gyrus. These results suggest that hippocampal neurogenesis is regulated by the amygdala.

本研究探讨杏仁核是否在海马神经发生的调节中发挥作用。切断大鼠穹窿海马伞可导致齿状回神经干细胞（溴脱氧尿苷阳性细胞）数量增加。大鼠杏仁核毁损后，齿状回神经干细胞数量减少。这些结果表明，海马神经发生是由杏仁核调节。