Chemopreventive effects of vitamin K cycle using human iPS cells

本研究的最终目的是从维生素K周期相关的遗传多态性信息中寻找改善癌症化疗和癌症化疗预防的途径。人类iPS细胞可作为多种药物代谢研究和癌症化学预防研究的合适检测手段。观察到维生素k周期相关基因多态性对华法林维持剂量的影响，这可能对癌症化疗期间使用华法林有一定的意义。

Final goal of this study was to find the way to improve the cancer chemotherapies and cancer chemo-preventions from the information of Vitamin K cycle-related genetic polymorphisms. The human iPS cells would be useful as an appropriate assay of a variety of drug metabolism study as well as the study of cancer chemo-preventions. The effect of Vitamin Kcycle-related genetic polymorphisms on warfarin maintenance dose was observed and this could havesome importance when warfarin prescribed during cancer chemotherapies.