Development of oncolytic adenovirus as a new therapeutic agent for treating human malignant mesothelioma

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Our new oncolytic adenovirus, in which adenoviral replication and HSV-TK suicide gene expression was transcriptional regulated by tumor-specific midkine promoter, achieved:1) tumor-specific lytic spread of the virus, 2) anti-tumor effect in subcutaneous, intrathoracic, and intraperitoneal mesothelioma mouse models, and 3) enhanced anti-tumor effect by suicide gene activation. The midkine-promoter regulated oncolytic virus represents a promising general strategy for oncolytic virotherapy of cancers withupregulated midkine expression, including malignant mesothelioma.