Establishment of anti human monoclonal antibody clones using cell-free protein translation system and development of automatic measurement system of human resistin.

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Resistin is one of the adipocytekines which induces insulin resistance and is thought to play an important role indiabetes and atherosclerosis. Human resistin serum concentration in the serum is critically determined by genomic polymorphisms, so it is an attractive target studying the relationship between gene and disease. To measure resistin concentration in higher sensitivity, we established anti human resistin monoclonal clones. We can analyze the underlining mechanism of diabetes and atherosclerosis from the point of genetic factor and environmental background.