New therapeutic strategy against age-related vascular injury targetedto L-type amino acid transporter
New therapeutic strategy against age-related vascular injury targetedto L-type amino acid transporter
针对L型氨基酸转运蛋白的年龄相关性血管损伤新治疗策略
批准号：
22590665
负责人：
KOZAKI Koichi
金额：
$2.83万
依托单位：
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2012
中文摘要
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英文摘要
A series of in vivo and in vitro experiments have revealed that L-type amino acid transporter 1 (LAT1) is pivotal for the growth of cultured vascular smooth muscle cells, and the growth of intimal thickening in the injured artery. And, therapeutic experiments targeted to LAT1 in the vascular smooth muscle cells inhibited intimal growth of the artery. These results indicate a new therapeutic LAT1-targeted strategy against age-related vascular injury.
期刊论文(0)
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会议论文
L-type amino acid transporter 1-mediated smooth muscle proliferation and viability, and evidence of its role in neointima formation
L型氨基酸转运蛋白1介导的平滑肌增殖和活力及其在新内膜形成中作用的证据
L型氨基酸转运蛋白1介导的平滑肌增殖和活力及其在新内膜形成中作用的证据
DOI：
--
发表时间：
2012
期刊：
影响因子：
--
作者：
[Kumiko Nagai, Hitomi Koshiba, Shigeki Shibata, Koichi Kozaki]
通讯作者：
Koichi Kozaki
DOI：
10.1111/j.1447-0594.2010.00625.x
发表时间：
2010-10-01
期刊：
GERIATRICS & GERONTOLOGY INTERNATIONAL
影响因子：
3.3
作者：
[Yamada, Shizuru, Akishita, Masahiro, Ouchi, Yasuyoshi]
通讯作者：
Ouchi, Yasuyoshi
Novel approach to vascular injury by targeting amino acid transporter LAT1
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批准号：19590543
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项目类别：Grant-in-Aid for Scientific Research (C)
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资助金额：$2.5万
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财政年份：2007
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负责人：KOZAKI Koichi
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依托单位：
Investigation of the usefulness of pentoxifylline for liver preservation
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批准号：08671387
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项目类别：Grant-in-Aid for Scientific Research (C)
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资助金额：$1.47万
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财政年份：1996
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负责人：KOZAKI Koichi
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依托单位：
海外基金
