New therapeutic strategy against age-related vascular injury targetedto L-type amino acid transporter

针对L型氨基酸转运蛋白的年龄相关性血管损伤新治疗策略

• 批准号: 22590665
• 负责人: KOZAKI Koichi
• 金额: $ 2.83万
• 依托单位: Kyorin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590665/
• 关键词: 老年医学; 血管傷害; LAT1; 新生内膜肥厚; ダブル欠損マウス; 血液脳関門; 細胞周期; 頸動脈; 内膜肥厚

A series of in vivo and in vitro experiments have revealed that L-type amino acid transporter 1 (LAT1) is pivotal for the growth of cultured vascular smooth muscle cells, and the growth of intimal thickening in the injured artery. And, therapeutic experiments targeted to LAT1 in the vascular smooth muscle cells inhibited intimal growth of the artery. These results indicate a new therapeutic LAT1-targeted strategy against age-related vascular injury.

一系列体内和体外实验表明，l型氨基酸转运蛋白1 （LAT1）对培养血管平滑肌细胞的生长和损伤动脉内膜增厚的生长起着关键作用。并且，针对血管平滑肌细胞中的LAT1的治疗实验抑制了动脉内膜的生长。这些结果表明了一种针对年龄相关血管损伤的新的靶向治疗策略。

项目成果

L-type amino acid transporter 1-mediated smooth muscle proliferation and viability, and evidence of its role in neointima formation

L型氨基酸转运蛋白1介导的平滑肌增殖和活力及其在新内膜形成中作用的证据

• 发表时间: 2012
• 作者: Kumiko Nagai;Hitomi Koshiba;Shigeki Shibata;Koichi Kozaki
• 通讯作者: Koichi Kozaki

Effects of dehydroepiandrosterone supplementation on cognitive function and activities of daily living in older women with mild to moderate cognitive impairment

• DOI: 10.1111/j.1447-0594.2010.00625.x
• 发表时间: 2010-10-01
• 期刊: GERIATRICS & GERONTOLOGY INTERNATIONAL
• 影响因子: 3.3
• 作者: Yamada, Shizuru;Akishita, Masahiro;Ouchi, Yasuyoshi
• 通讯作者: Ouchi, Yasuyoshi