The association between genetic variations of the neuronal nicotinic cholinergic receptors and smoking-related lung diseases

神经元烟碱胆碱能受体的遗传变异与吸烟相关肺部疾病之间的关联

• 批准号: 22590845
• 负责人: KIDA Kozui
• 金额: $ 3万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590845/
• 关键词: 閉塞性肺疾患; 喫煙; 肺気腫; ニコチン受容体; 遺伝子多型; COPD; 肺癌; 肺線維症

The study population comprised 366 current or ex-smokers including 247 COPD patients. Two of the SNPs, rs3743078 and rs660652, in CHRNB4-CHRNA3-CHRNA5 showed an association with %LAA in the upper region of the lungs (p = 0.0050 and 0.0038, respectively) and were also associated with the mRNA expression of CHRNA3 and CHRNA5. CHRNA3 was expressed also in the lung, confirmed pathologically.

研究人群包括366名现在或以前吸烟的人，其中包括247名COPD患者。ChRNB4-CHRNA3-CHRNA5中的两个SNP rs3743078和rs660652与肺上区的%LAA相关(p分别为0.0050和0.0038)，并与ChRNA3和ChRNA5mRNA的表达有关。病理证实，CHRNA3在肺中也有表达。

项目成果

Association between emphysema and genetic variations of CHRNA3

肺气肿与 CHRNA3 遗传变异之间的关联

• 发表时间: 2011
• 作者: Takeo Ishii;Kozui Kida;他
• 通讯作者: 他