Analysis of the roles of mDia in refractory pulmonary diseases

本研究旨在分析mDia作为Rho效应物在难治性肺部疾病中的作用，阐明其发病机制并开发新的治疗方法。在急性哮喘模型中，与野生型小鼠相比，mDia1缺陷小鼠的支气管肺泡灌洗液中总细胞和嗜酸性粒细胞数量较少，Th2细胞因子浓度较低。与哮喘野生型小鼠相比，mDia1缺陷型哮喘小鼠的气道高反应性也降低。因此，mDia1有助于过敏性气道炎症，可以成为治疗靶点。

This study aims to analyze the roles of mDia known as Rho effectors in refractory pulmonary diseases and to elucidate their pathogenesis and develop novel therapies. In an acute asthma model, mice deficient in mDia1 showed less numbers of total cells and eosinophils and lower concentrations of Th2 cytokines in bronchoalveolar lavage fluid than wild-type mice. Airway hyperresponsiveness in asthmatic mice deficient in mDia1 was also reduced as compared to asthmatic wild-type mice. Thus, mDia1 contributes to allergic airway inflammation and can be a therapeutic target.