Association of serum cystatin C with the risk of the development of cardiovascular disease in a general Japanese population: the Hisayama Study

该项目的目的是调查 3,328 名 40 岁或以上的日本社区居民中 sCysC 与动脉粥样硬化疾病风险之间的关系。首先，我们研究了 sCysC 与外周动脉疾病 (PAD) 患病率之间的关系，外周动脉疾病 (PAD) 定义为踝臂指数 <0.9。因此，未经调整的 PAD 患病率随着 sCysC 水平的升高而线性增加。然而，在多变量调整分析中没有证据表明存在显着关系。接下来，我们在上述人群中进行的平均 7.1 年的随访研究中估计了 sCysC 与心血管风险的关联。较高的 sCysC 水平与未调整的心血管疾病发病率显着相关，但在调整混杂因素后，这种显着相关性消失。最后，我们评估了 sCysC 估计肾小球滤过率（eGFR-CysC）与上述随访数据中心血管疾病发生风险和全因死亡率之间的关系。较低的 eGFR-CysC 是心血管疾病和全因死亡率的危险因素。

The aims of this project were to investigate the association of sCysC on the risk of atherosclerotic disease among 3,328 community-dwelling Japanese individuals aged 40 years or older. First, we investigated the relationship between sCysC and prevalence of peripheral arterial disease (PAD) defined as ankle-brachial index <0.9. As a result, the unadjusted prevalence of PAD increased linearly with elevating sCysC levels. However, there was no evidence of the significant relationship in the multivariate-adjusted analysis. Next, we estimated the association of sCysC and the cardiovascular risk in an average 7.1-year follow-up study conducted in the above population. Higher sCysC levels were associated significantly with the unadjusted incidence of cardiovascular disease, but this significant association disappeared after adjusting confounding factors.Finally, we assessed the relationship between estimated glomerular filtration rate with sCysC (eGFR-CysC) and the risk of incident cardiovascular disease and all-cause mortalityin the above follow-up data. Lower eGFR-CysC was a risk factor for the incident cardiovascular disease and all-cause mortality.