Research on the role of Omi/HtrA2 in the abnormal mitochondria in patients with Parkinson's disease

我们证实，路易体的XIAP，这是负调控Omi/HtrA 2的免疫反应，和XIAP和Omi/HtrA 2免疫反应共定位于路易体。我们的研究重点是细胞色素c、Apaf-1和caspase-9在路易体中的免疫组织化学定位。我们还发现，裂解的caspase-9免疫反应定位于路易体，这表明caspase-9可能在帕金森病患者的大脑中被激活。

We confirmed that Lewy bodies were immunoreactive for XIAP, which is negatively regulated by Omi/HtrA2, and that XIAP and Omi/HtrA2 immunoreactivity were co-localized to Lewy bodies. Our research focused on apoptosome-related proteins demonstrated the immunohistochemical localization of cytochrome c, Apaf-1 and caspase-9 in Lewy bodies. We also found that cleaved caspase-9 immunoreactivity was localized to Lewy bodies, suggesting that caspase-9 may be activated in brains from patients with Parkinson’s disease.