Research on the role of Omi/HtrA2 in the abnormal mitochondria in patients with Parkinson's disease

Omi/HtrA2在帕金森病患者线粒体异常中的作用研究

• 批准号: 22590930
• 负责人: KAWAMOTO Yasuhiro
• 金额: $ 2.5万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590930/
• 关键词: Omi/HtrA2; パーキンソン病; ミトコンドリア; アポトーシス; XIAP; α-synuclein; parkin

We confirmed that Lewy bodies were immunoreactive for XIAP, which is negatively regulated by Omi/HtrA2, and that XIAP and Omi/HtrA2 immunoreactivity were co-localized to Lewy bodies. Our research focused on apoptosome-related proteins demonstrated the immunohistochemical localization of cytochrome c, Apaf-1 and caspase-9 in Lewy bodies. We also found that cleaved caspase-9 immunoreactivity was localized to Lewy bodies, suggesting that caspase-9 may be activated in brains from patients with Parkinson’s disease.

我们证实，路易体的XIAP，这是负调控Omi/HtrA 2的免疫反应，和XIAP和Omi/HtrA 2免疫反应共定位于路易体。我们的研究重点是细胞色素c、Apaf-1和caspase-9在路易体中的免疫组织化学定位。我们还发现，裂解的caspase-9免疫反应定位于路易体，这表明caspase-9可能在帕金森病患者的大脑中被激活。

项目成果

Localization of HtrA2/Omi immunoreactivity in brains affected by Alzheimer’s disease

• DOI: 10.1097/wnr.0b013e328340a731
• 发表时间: 2010-12
• 期刊: NeuroReport
• 影响因子: 1.7
• 作者: Y. Kawamoto;Hidefumi Ito;Yoshito Kobayashi;Yasuyuki Suzuki;R. Takahashi

多系統萎縮症患者脳内の封入体におけるXIAPの蓄積

XIAP 在多系统萎缩患者大脑包涵体中的积累

• 发表时间: 2012
• 作者: Morozumi S;Koike H;Tomita M;Kawagashira Y;Iijima M;Kasuno M;Hattori N;Tanaka F;Sobue G;河本恭裕
• 通讯作者: 河本恭裕

パーキンソン病患者の中脳黒質のLewy小体におけるapoptosome関連タンパク質の集積

帕金森病患者黑质路易体中凋亡体相关蛋白的积累

• 作者: Kishigami H;Nagano S;Bush AI;Sakoda S. Monomerized Cu;Melina V.;河本恭裕
• 通讯作者: 河本恭裕

XIAP immunoreactivity in glial and neuronal cytoplasmic inclusions in multiple system atrophy.

多系统萎缩中神经胶质和神经元细胞质内含物的 XIAP 免疫反应性。

• DOI: 10.5414/np300610
• 发表时间: 2014
• 期刊: Clin Neuropathol.
• 作者: Kawamoto Y;Ito H;Ihara M;Takahashi R.
• 通讯作者: Takahashi R.