Functional analysis of the novel intestinal hormone, IBCAP withincretin-like activity

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We identified a gene of IBCAP with an incretin-like activity. We developed to assessment of IBCAP activity as an indexing of beta-cells proliferation, and we identified candidate of sequences activated peptides of IBCAP gene. Also, transgenic mice over-expressing IBCAP was demonstrated to have increased amount of pancreatic β-cells, whereas gene-knockouts of the factor resulted in a marked decrease of pancreatic islets. Our findings strongly suggested IBCAP as a major player in the control of the amount of pancreatic islets and β-cells. Our results demonstrated that we assume that IBCAP can be another potential therapeutic target for diabetes.