Functional analysis of the novel intestinal hormone, IBCAP withincretin-like activity

新型肠道激素 IBCAP 肠促胰素样活性的功能分析

• 批准号: 22590992
• 负责人: TOYOSHIMA Hideo
• 金额: $ 2.83万
• 依托单位: Saitama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590992/
• 关键词: 糖尿病; 消化管ホルモン; 新規分泌タンパク

We identified a gene of IBCAP with an incretin-like activity. We developed to assessment of IBCAP activity as an indexing of beta-cells proliferation, and we identified candidate of sequences activated peptides of IBCAP gene. Also, transgenic mice over-expressing IBCAP was demonstrated to have increased amount of pancreatic β-cells, whereas gene-knockouts of the factor resulted in a marked decrease of pancreatic islets. Our findings strongly suggested IBCAP as a major player in the control of the amount of pancreatic islets and β-cells. Our results demonstrated that we assume that IBCAP can be another potential therapeutic target for diabetes.

我们鉴定了一个具有肠促胰岛素样活性的IBCAP基因。本研究将IBCAP活性作为β细胞增殖的一个指标，并筛选了IBCAP基因序列激活肽的候选序列。此外，过表达IBCAP的转基因小鼠被证明具有增加的胰腺β细胞的量，而该因子的基因敲除导致胰岛的显著减少。我们的研究结果强烈表明IBCAP是控制胰岛和β细胞数量的主要参与者。我们的研究结果表明，我们认为IBCAP可能是糖尿病的另一个潜在治疗靶点。

项目成果

IBCAP, Intestine- specific Secretory Protein with Incretin-like Activity

IBCAP，具有肠促胰岛素样活性的肠特异性分泌蛋白

• DOI: 10.2337/db11-1929-2041
• 发表时间: 2011
• 期刊: Diabetes
• 影响因子: 7.7
• 作者: Yokoo T;Suzuki H;Shimano H;Watanabe K;Kawakami M;Yamada N;Okazaki Y;Toyoshima H
• 通讯作者: Toyoshima H

Effect of IBCAP, a Novel Intestine-specific Secretory Protein, on Pancreaticβ-cell Differentiation

新型肠道特异性分泌蛋白 IBCAP 对胰腺β细胞分化的影响

• 发表时间: 2012
• 作者: Yokoo T;Watanabe K;Iida KT;Suzuki H;Shimano H;Yamada N;Okazaki Y;Toyoshima H.
• 通讯作者: Toyoshima H.

Transgenic Mice Expressing an Intestine-Specific Secretory Protein, IBCAP (Formerly CF266), Demonstrates Pancreatic β-Cell Augmenting Activity.

表达肠道特异性分泌蛋白 IBCAP（以前称为 CF266）的转基因小鼠表现出胰腺 β 细胞增强活性。

• 发表时间: 2009
• 作者: Tomotaka Yokoo;Kazuhisa Watanabe
• 通讯作者: Kazuhisa Watanabe

IBCAP; discovery of another intestinal hormone with beta cell augmenting activity

IBCAP；

• 发表时间: 2011
• 作者: 長嶋一昭;他;Toyoshima H [invited speaker]
• 通讯作者: Toyoshima H [invited speaker]

新規消化管特異的分泌因子IBCAPの機能解析および糖尿病治療への可能性

新型胃肠道特异性分泌因子 IBCAP 的功能分析及其治疗糖尿病的潜力

• 发表时间: 2011
• 作者: 豊島秀男 [招待演者];横尾友隆;鈴木浩明;石川三衛;川上正舒;島野仁;山田信博;岡崎康司
• 通讯作者: 岡崎康司