A classification and identification of the asthmatic disease-inducedCD4 T cell subset with costimulatory molecule marker

点击翻译按钮获取中文摘要

We revealed that antigen-specific CD4 T cells were separated into CD27+and CD27-populations in the lymph node from OVA-immunized DO11.10/Rag-2-/-mice.The CD27+CD4 T cells produced a high level of IFN-・, representing Th1 cells. In contrast, CD27-CD4 T cells produced high levels of IL-4, IL-5, and IL-13, representing Th2 cells.Eosinophil infiltration and Th2 cytokine production in the lung and the population of CD27-Th2 cells was significantly reduced by the anti-CD70 mAb treatment. These results indicated an important role for CD27 in the development of pathogenic Th2 cells in a murine model of allergic lung inflammation.