A classification and identification of the asthmatic disease-inducedCD4 T cell subset with costimulatory molecule marker

共刺激分子标记对哮喘病诱导的CD4 T细胞亚群的分类与鉴定

• 批准号: 22591098
• 负责人: AKIBA Hisaya
• 金额: $ 2.41万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591098/
• 关键词: 補助シグナル分子; Th1/Th2; 喘息モデルマウス; 関節炎モデルマウス; TIM-4; 関節炎マウス; CD70-CD27; T細胞分化; コラーゲン誘発性関節炎マウス

We revealed that antigen-specific CD4 T cells were separated into CD27+and CD27-populations in the lymph node from OVA-immunized DO11.10/Rag-2-/-mice.The CD27+CD4 T cells produced a high level of IFN-・, representing Th1 cells. In contrast, CD27-CD4 T cells produced high levels of IL-4, IL-5, and IL-13, representing Th2 cells.Eosinophil infiltration and Th2 cytokine production in the lung and the population of CD27-Th2 cells was significantly reduced by the anti-CD70 mAb treatment. These results indicated an important role for CD27 in the development of pathogenic Th2 cells in a murine model of allergic lung inflammation.

我们发现抗原特异性CD4 T细胞在ova免疫的DO11.10/ rag2 -/-小鼠淋巴结中被分离成CD27+和CD27群。CD27+CD4 T细胞产生高水平的IFN-·，代表Th1细胞。相比之下，CD27-CD4 T细胞产生高水平的IL-4、IL-5和IL-13，代表Th2细胞。抗cd70单抗可显著降低肺中嗜酸性粒细胞的浸润和Th2细胞因子的产生以及CD27-Th2细胞的数量。这些结果表明CD27在小鼠变应性肺炎症模型中致病性Th2细胞的发育中起重要作用。

项目成果

TIM-3: a novel regulatory molecule of alloimmune activation.

• DOI: 10.4049/jimmunol.0903435
• 发表时间: 2010-11-15
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Boenisch O;D'Addio F;Watanabe T;Elyaman W;Magee CN;Yeung MY;Padera RF;Rodig SJ;Murayama T;Tanaka K;Yuan X;Ueno T;Jurisch A;Mfarrej B;Akiba H;Yagita H;Najafian N
• 通讯作者: Najafian N

RANKL is a critical factor for the differentiation, maintenance, and survival of antigen-sampling M cells in the intestine.

RANKL 是肠道中抗原采样 M 细胞分化、维持和存活的关键因素。

• 发表时间: 2010
• 作者: 古田繭子、稲澤譲治;他;Feau S;畠山昌則;Knoop KA
• 通讯作者: Knoop KA

Expression and Function of Inducible Costimulator in Patients with Ocular Behcet's Disease : Possible Involvement in IFN and IL-17Production

眼部白塞氏病患者诱导共刺激物的表达和功能：可能参与 IFN 和 IL-17 的产生

• 发表时间: 2010
• 作者: Usui Y;et al.
• 通讯作者: et al.

TIM-4の喘息モデルマウスにおける役割の検討

检查 TIM-4 在哮喘模型小鼠中的作用

• 发表时间: 2010
• 作者: YONG MEI;Fujimoto M;Ohkawara T; Yang L;Serada S;Tsunoda S;Naka T.;伊藤潤
• 通讯作者: 伊藤潤

TIM4 regulates asthmatic response in a murine model of asthma.

TIM4 调节小鼠哮喘模型中的哮喘反应。

• 发表时间: 2010
• 作者: Ito;J.
• 通讯作者: J.