Intratumoral heterogeneity in brain tumor using PET molecular imaging

异质性是恶性肿瘤的公认特征。据报道，它与影响治疗耐药性的因素有关，如组织学特征（包括细胞增殖、坏死）和生理特征（包括血管化程度、基因表达、能量代谢和氧合）。所有这些肿瘤内异质性都可能影响肿瘤在患者体内的生物学行为，表现为预后和治疗反应的可变性。本研究的目的是定量测量肿瘤内的异质性，并描述原发性脑肿瘤患者中F-18 FDG、F-18 FLT和C-11蛋氨酸分布的差异。

Heterogeneity is a recognized characteristic of malignant tumor. It has been reported to be associated with factors that influence resistance to therapy such as histological features including cellular proliferation, necrosis, and physiological features including degree of vascularity, gene expression, energy metabolism, and oxygenation. All these aspects of intratumoral heterogeneity may affect the biological behavior of tumors in patients, which may manifest as variability in prognosis and treatment response. The purpose of this study was to quantitatively measure intratumoral heterogeneity, and to delineate the differences in the distribution of F-18 FDG, F-18 FLT, and C-11 methionine in patients with primary brain tumors.