Intratumoral heterogeneity in brain tumor using PET molecular imaging

使用 PET 分子成像研究脑肿瘤的瘤内异质性

• 批准号: 22591337
• 负责人: NISHIYAMA Yoshihiro
• 金额: $ 2.91万
• 依托单位: Kagawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591337/
• 关键词: PET 検査; F-18 FDG; C-11 methionine; 分子イメージング; 不均一性; 脳腫瘍; PET検査; F-18 FLT

Heterogeneity is a recognized characteristic of malignant tumor. It has been reported to be associated with factors that influence resistance to therapy such as histological features including cellular proliferation, necrosis, and physiological features including degree of vascularity, gene expression, energy metabolism, and oxygenation. All these aspects of intratumoral heterogeneity may affect the biological behavior of tumors in patients, which may manifest as variability in prognosis and treatment response. The purpose of this study was to quantitatively measure intratumoral heterogeneity, and to delineate the differences in the distribution of F-18 FDG, F-18 FLT, and C-11 methionine in patients with primary brain tumors.

异质性是公认的恶性肿瘤的特征。据报道，它与影响抵抗治疗的因素有关，例如组织学特征，包括细胞增殖、坏死，以及生理特征，包括血管程度、基因表达、能量代谢和氧合。肿瘤内异质性的所有这些方面都可能影响患者的肿瘤生物学行为，这可能表现为预后和治疗反应的差异性。本研究的目的是定量测量肿瘤内的异质性，并描述F-18FDG、F-18Flt和C-11蛋氨酸在原发性脑肿瘤患者中的分布差异。

项目成果

Intratumoral FDG metabolic heterogeneity in newly diagnosed malignant primary brain tumor : comparison with glioblastoma and lymphoma

新诊断的恶性原发性脑肿瘤瘤内FDG代谢异质性：与胶质母细胞瘤和淋巴瘤的比较

• 发表时间: 2011
• 作者: Aga Fumitoshi ; Yamamoto Yuka ; Kawai Nobuyuki;Kudomi Nobuyuki;Nishiyama Yoshihiro ; 他;Aga Fumitoshi
• 通讯作者: Aga Fumitoshi

Pixel-based analysis of 18F-FDG, 18F-FLT, and 11C-methionine PET in high-grade brain gliomas

对高级脑胶质瘤中 18F-FDG、18F-FLT 和 11C-蛋氨酸 PET 进行基于像素的分析

• 发表时间: 2012
• 作者: Aga Fumitoshi ; Yamamoto Yuka ; Kawai Nobuyuki;Kudomi Nobuyuki;Nishiyama Yoshihiro;他
• 通讯作者: 他

Intratumoral FDG metabolic heterogeneity in newly diagnosed malignant primary brain tumor: comparison with glioblastoma and lymphoma s

新诊断的恶性原发性脑肿瘤瘤内 FDG 代谢异质性：与胶质母细胞瘤和淋巴瘤的比较

• 发表时间: 2011
• 作者: Aga Fumitoshi ; Yamamoto Yuka ; Kawai Nobuyuki;Kudomi Nobuyuki;Nishiyama Yoshihiro ; 他
• 通讯作者: 他

Correlation of biological aggressiveness assessed by 11C-methionine PET and hypoxic burden assessed by 18F-fluoromisonidazole PET in newly diagnosed glioblastoma

• DOI: 10.1007/s00259-010-1645-4
• 发表时间: 2011-03-01
• 期刊: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
• 影响因子: 9.1
• 作者: Kawai, Nobuyuki;Maeda, Yukito;Tamiya, Takashi
• 通讯作者: Tamiya, Takashi

Assessment of hypoxia using F-18 fluoromisonidazole PET in brain gliomas and correlation of F-18 FDG PET and Gd-DTPA enhanced MRI

F-18氟米索硝唑PET评估脑胶质瘤缺氧情况及F-18 FDG PET与Gd-DTPA增强MRI的相关性

• 发表时间: 2010
• 作者: Aga Fumitoshi ; Yamamoto Yuka ; Kawai Nobuyuki;Kudomi Nobuyuki;Nishiyama Yoshihiro ; 他;Aga Fumitoshi;Yamamoto Yuka
• 通讯作者: Yamamoto Yuka