Development and evaluation of quantification for BF-227 amyloid PET imaging.

本研究的目的是建立一种定量评价BF-227淀粉样PET的方法。使用BF-227模板进行空间归一化的精度等于或高于使用MRI模板进行空间归一化的精度。本研究提出的确定小脑参考区的新方法可用于BF-227 PET的SUVR（标准摄取值比）成像。部分体积校正和分辨率恢复不能区分皮层和白质之间的堆积。算法还需要进一步改进。该方法被证明对BF-227 PET有效，可应用于其他淀粉样蛋白成像示踪剂。

The purpose of this study was to establish a method for evaluating quantitatively BF-227 amyloid PET. Spatial normalization using BF-227 template showed equal to or higher precision than spatial normalization using MRI template. The new method proposed in this study to determine cerebellar reference region is useful for making SUVR (standard uptake value ratio) image for BF-227 PET. Partial volume correction with resolution recovery did not discriminate the accumulation between the cortex and white matter. Further improvement of algorithm is necessary. The methods proved to be useful for BF-227 PET can be applied to other amyloid imaging tracers.