Clinical significance of ubiquitin-like protein in esophageal squamous cell carcinoma

泛素样蛋白在食管鳞癌中的临床意义

• 批准号: 22591470
• 负责人: ISHIBASHI Yoshio
• 金额: $ 2.83万
• 依托单位: Jikei University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591470/
• 关键词: ユビキチン; SUMO-1; 食道癌

SUMO-1(small ubiquitin-related modifier-1) is a novel ubiquitin -like protein that is conjugated like ubiquitin by a set of enzymes to cellular regulatory proteins including oncogenes and tumor suppressor genes. In this study, we aimed to investigate the significance of SUMO-1 expressions in esophageal cancer as a prognostic factor. In an esophagus cancer, revelation of SUMO-1 was accepted with a core or cytoplasm and SUMO-1 binding protein of varieties was accepted. The high revelation group had intentionally much lymph node metastasis and vessel invasion. Moreover, the life prognosis also accepted the tendency for a high revelation group to be bad.

SUMO-1（small ubiquitin-related modifiers-1）是一种新型的泛素样蛋白，它通过一系列酶与细胞调控蛋白（包括癌基因和抑癌基因）结合。在这项研究中，我们的目的是探讨SUMO-1的表达在食管癌作为一个预后因素的意义。在食管癌中，SUMO-1的显示被接受为具有核心或细胞质，并且接受多种SUMO-1结合蛋白。高暴露组有意多淋巴结转移和血管侵犯。此外，生活预后也接受了高启示组的倾向是坏的。

项目成果

細胞内ポリユビキチン鎖の定量による化学物質の毒性発現機序の検討

通过量化细胞内多聚泛素链来检查化学物质的毒性机制

• 发表时间: 2011
• 作者: 高田耕司,青木勝彦,山田宙史,岩室祥一;大川 清
• 通讯作者: 大川 清

Changes in the properties of renal proteins in mice repeatedly administered with cadmium

反复给予镉的小鼠肾蛋白性质的变化

• 发表时间: 2010
• 作者: 高田 耕司;福田 隆浩;青木 勝彦;加藤 尚志;大川 清
• 通讯作者: 大川 清

SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7

• DOI: 10.1093/hmg/ddp478
• 发表时间: 2010-01-01
• 期刊: HUMAN MOLECULAR GENETICS
• 影响因子: 3.5
• 作者: Janer, Alexandre;Werner, Andreas;Sittler, Annie
• 通讯作者: Sittler, Annie

Quantitative analysis of free ubiquitin and multi-ubiquitin chain in precancerous and cancerous gastric tissues.

癌前和癌变胃组织中游离泛素和多泛素链的定量分析。

• 发表时间: 2010
• 作者: Ishibashi Y;Omura N;Kashiwagi H,他
• 通讯作者: Kashiwagi H,他

Effect of laparoscopic esophagomyotomy on chest pain associated with achalasia and prediction of therapeutic outcomes

• DOI: 10.1007/s00464-010-1314-5
• 发表时间: 2011-04-01
• 期刊: SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
• 影响因子: 3.1
• 作者: Omura, Nobuo;Kashiwagi, Hideyuki;Yanaga, Katsuhiko
• 通讯作者: Yanaga, Katsuhiko