Clinical significance of ubiquitin-like protein in esophageal squamous cell carcinoma

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SUMO-1(small ubiquitin-related modifier-1) is a novel ubiquitin -like protein that is conjugated like ubiquitin by a set of enzymes to cellular regulatory proteins including oncogenes and tumor suppressor genes. In this study, we aimed to investigate the significance of SUMO-1 expressions in esophageal cancer as a prognostic factor. In an esophagus cancer, revelation of SUMO-1 was accepted with a core or cytoplasm and SUMO-1 binding protein of varieties was accepted. The high revelation group had intentionally much lymph node metastasis and vessel invasion. Moreover, the life prognosis also accepted the tendency for a high revelation group to be bad.