Development of predictive markers for metastasis in gastric cancer

胃癌转移预测标记物的开发

• 批准号: 22591472
• 负责人: TERASHIMA Masanori
• 金额: $ 2.91万
• 依托单位: Shizuoka Cancer Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591472/
• 关键词: 癌; 遺伝子; 腫瘍マーカー; 微小転移; 外科; 転移; 種瘍マーカー

We evaluated the possibility to establish predictive markers for gastric cancer metastasis using splicing variant developed from highly metastatic gastric cancer cell lines. Peripheral blood was corrected from 94 patient with gastric cancer and expression of ARHGDIBsv1, ALD0G4b, XAF1sv3 were measured. Expression level of each variant was compared with clinicopathologic factors. ARHGDIBsv1 expression was up regulated in advanced cancer, and XAF1sv3 expression was up regulated in patients with undifferentiated type of cancer. However, there was no significant correlation between gene expression and tumor metastasis. With respect to newly marker development, we found the up regulation of secretary protein isoform Quiescin Q6 sulfhydryl oxidase 1 in highly metastatic gastric cancer cell lines.

我们评估了使用从高转移性胃癌细胞系开发的剪接变体建立胃癌转移预测标志物的可能性。对94例胃癌患者外周血进行校正，检测ARHGDIBsv1、ALD0G4b、XAF1sv3的表达。将每个变体的表达水平与临床病理因素进行比较。ARHGDIBsv1在晚期肿瘤中表达上调，XAF 1sv3在未分化型肿瘤中表达上调。然而，基因表达与肿瘤转移无明显相关性。关于新标记物的开发，我们发现分泌蛋白异构体Quiescin Q6巯基氧化酶1在高转移性胃癌细胞系中上调。

项目成果

Final results of a phase II multicenter study of neoadjuvant S-1 and irinotecan in patients with locally advanced gastric cancer.

新辅助 S-1 和伊立替康治疗局部晚期胃癌患者的 II 期多中心研究的最终结果。

• 发表时间: 2013
• 作者: Fischera A;Zoccali M;Kono T;伊藤誠二;Terashima M
• 通讯作者: Terashima M

The Impact of Preoperative Lymph Node Size on Long-Term outcome following curative gastrectomy for gastric cancer.

术前淋巴结大小对胃癌根治性胃切除术后长期结果的影响。

• DOI: 10.1245/s10434-012-2699-2
• 发表时间: 2013
• 期刊: Ann Surg Oncol
• 影响因子: 3.7
• 作者: Tokunaga M;Tanizawa Y;Bando E;Kawamura T;Terashima M
• 通讯作者: Terashima M

Placenta-specific novel splice variants of Rho GDP dissociation inhibitor β are highly expressed in cancerous cells.

• DOI: 10.1186/1756-0500-5-666
• 发表时间: 2012-12-03
• 期刊: BMC research notes
• 影响因子: 1.8
• 作者: Hatakeyama K;Fukuda Y;Ohshima K;Terashima M;Yamaguchi K;Mochizuki T
• 通讯作者: Mochizuki T

Risk of lymph node metastases from intramucosal gastric cancer in relation to histological types: how to manage the mixed histological type for endoscopic submucosal dissection

• DOI: 10.1007/s10120-012-0220-z
• 发表时间: 2013-10-01
• 期刊: GASTRIC CANCER
• 影响因子: 7.4
• 作者: Takizawa, Kohei;Ono, Hiroyuki;Nakajima, Takashi
• 通讯作者: Nakajima, Takashi

胃がん患者末梢血中におけるスプライシングバリアント発現レベルの定量化

胃癌患者外周血剪接变异体表达水平的定量

• 发表时间: 2012
• 作者: 河野 透;岡本耕太郎;高後 裕;畠山慶一
• 通讯作者: 畠山慶一