Boron uptake enhancement by redox control in boron neutron capture therapy

在之前的研究中，我们报道了在BSO和BSH同时给药的大鼠皮下肿瘤模型中，在BNCT中联合使用硼正丁酸钠（BSH）和丁硫氨酸亚砜胺（BSO）增强了组织硼的摄取。在本研究中，我们采用脑肿瘤模型，在BSH注射前用BSO预处理大鼠。通过这种方法，血硼浓度比BSO-（负）组高约20倍，并且在其他组织（脑肿瘤、皮下肿瘤、肌肉、肝脏、肾脏）中也观察到同样的浓度升高趋势。我们认为肿瘤特异性氧化还原调节机制是增强肿瘤对硼吸收的必要条件。

In the previous study, we reported that combined use of sodium borocaptate (BSH) and buthionine sulfoximine (BSO) in BNCT enhanced tissue boron uptake in the rat subcutaneous tumor model, where BSO and BSH were administered simultaneously. In the present study, we used a brain tumor model, and rats were pretreated with BSO before BSH injection. By this method, the blood boron concentration was about 20 times higher in comparison with the BSO- (minus) group, and in other tissues (brain tumor, subcutaneous tumor, muscles, liver, kidney) the same tendency of increasing concentration was observed. We suggest that tumor-specific redox regulatory mechanisms are necessary to enhance tumor uptake of boron.