Effects of repeated crush injuries on motor functional recovery of thesciatic nerve

为探讨反复挤压伤对周围神经运动功能恢复的影响，采用大鼠坐骨神经反复挤压伤模型，以SSI、胫前肌纤维大小及其神经纤维再支配为指标，观察坐骨神经功能恢复情况。单挤压伤，完全恢复伤后第4周相比，双挤压伤导致延迟，但完全恢复伤后第6周，而三重挤压伤导致再生过程中的显着延迟与不完全恢复在第8周的实验期间。三重挤压大鼠的肌纤维尺寸在损伤后4周没有恢复到正常范围，尽管其在单次挤压大鼠的正常尺寸。这些结果表明，反复挤压损伤抑制受损坐骨神经的运动功能恢复，如延迟和不完全再生、萎缩的肌纤维和延迟的神经再支配所证明的。

The present study was conducted to examine whether repeated crush injuries have significant effects on motor functional recovery of peripheral nerves.Repeated crush injuries of the sciatic nerve were inflicted on adult rats at 1 -week intervals, and functionality of the sciatic nerve was assessed by the SSI, tibiali s anterior muscle fibers size,and its fiber reinnervation. Compared to single crush injuries, which completely recovered by post-injury week 4, double crush injuries resulted in retarded, but complete recovery by post-injury week 6, whereas triple crush injuries resulted in marked retardation in the regenerative process with incomplete recovery during week 8 of the experimental period. Muscle fiber size for rats with triple crush did not recover to normal range at post-injury week 4, despite its normal size for rats with single crush. These results indicate that repeated crush injuries inhibit motor functional recovery of the damaged sciatic nerve, as evidenced by delayed and incomplete regeneration, atrophied muscle fibers, and delayed reinnervation.