Clinical research of CD24 expression and the importance on tumor progression.
Clinical research of CD24 expression and the importance on tumor progression.
批准号:
21591691
负责人:
KATO Hiroyuki
金额:
$2.41万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Mortality rates due to gastric cancer are high in Japan. To improve patient prognosis, new biomarkers for diagnosis and treatment are urgently required. In this study we investigated the role of CD24, a cell adhesion glycoprotein implicated in tumor cell proliferation, which is used as a prognostic marker in various cancers.CD24 upregulation was significantly correlated with depth of invasion and pathological high stage. We observed a relationship between high CD24 expression and lymph node metastasis, venous invasion and lymphatic invasion, however there were not statistically significant. CD24 expression tended to be higher in cell lines derived from differentiated gastric carcinoma, including those derived from lymph node metastasis.CD24 expression is a potential biomarker for digestive cancer prognosis, and provides a new molecular target for therapeutic strategies.
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DOI:
10.1245/s10434-008-0252-0
发表时间:
2009-02-01
期刊:
ANNALS OF SURGICAL ONCOLOGY
影响因子:
3.7
作者:
[Sano, Akihiko, Kato, Hiroyuki, Kuwano, Hiroyuki]
通讯作者:
Kuwano, Hiroyuki
DOI:
10.5754/hge12763
发表时间:
2013-06-01
期刊:
HEPATO-GASTROENTEROLOGY
影响因子:
--
作者:
[Takahashi, Masakazu, Nakajima, Masanobu, Kato, Hiroyuki]
通讯作者:
Kato, Hiroyuki
食道癌切除症例におけるCD24 発現の検討
食管癌切除病例中CD24表达的检测
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Nakajima M, Kato H, Miyazaki T, FukuchiM, Masuda N, Fukai Y, Sohda M, Ahmad F, Kuwano H, 佐野 彰彦]
通讯作者:
佐野 彰彦
Comprehensive Analysis of Genes Involved in the Malignancy of Gastrointestinal Stromal Tumors
胃肠道间质瘤恶性相关基因的综合分析
DOI:
--
发表时间:
2010
期刊:
Anticancer Research
影响因子:
2
作者:
[Hadisaputri YE, Miyazaki T, Suzuki S, Yokobori T, Kobayashi T, Tanaka N, Inose T, Sohda M, Kuwano H., Tsumuraya M]
通讯作者:
Tsumuraya M
胃癌におけるCD24 発現と臨床病理学的検討
胃癌中CD24的表达及临床病理学检查
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Yamauchi H, Asao T, Yazawa S, Kigure W, Morita H, Kobayashi T, Kato T, Yajima R, Tabe Y, Yamaki S, Fukasawa T, Fujii T, Tsutsumi S, Kuwano H, 高橋 雅一]
通讯作者:
高橋 雅一
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