Clinical research of CD24 expression and the importance on tumor progression.

CD24表达的临床研究及其对肿瘤进展的重要性。

• 批准号: 21591691
• 负责人: KATO Hiroyuki
• 金额: $ 2.41万
• 依托单位: Dokkyo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591691/
• 关键词: 食道外科学; CD24; 免疫染色; 胃癌

Mortality rates due to gastric cancer are high in Japan. To improve patient prognosis, new biomarkers for diagnosis and treatment are urgently required. In this study we investigated the role of CD24, a cell adhesion glycoprotein implicated in tumor cell proliferation, which is used as a prognostic marker in various cancers.CD24 upregulation was significantly correlated with depth of invasion and pathological high stage. We observed a relationship between high CD24 expression and lymph node metastasis, venous invasion and lymphatic invasion, however there were not statistically significant. CD24 expression tended to be higher in cell lines derived from differentiated gastric carcinoma, including those derived from lymph node metastasis.CD24 expression is a potential biomarker for digestive cancer prognosis, and provides a new molecular target for therapeutic strategies.

在日本，胃癌的死亡率很高。为了改善患者预后，迫切需要新的诊断和治疗生物标志物。在这项研究中，我们研究了CD24的作用，CD24是一种细胞粘附糖蛋白，与肿瘤细胞增殖有关，被用作各种癌症的预后标志物。CD24表达上调与浸润深度及病理高分期显著相关。我们观察到CD24高表达与淋巴结转移、静脉浸润和淋巴浸润相关，但无统计学意义。CD24的表达在分化的胃癌细胞系中趋于较高，包括淋巴结转移的胃癌细胞系。CD24的表达是一种潜在的消化道肿瘤预后的生物标志物，并为治疗策略提供了新的分子靶点。

项目成果

CD24 Expression Is a Novel Prognostic Factor in Esophageal Squamous Cell Carcinoma

• DOI: 10.1245/s10434-008-0252-0
• 发表时间: 2009-02-01
• 期刊: ANNALS OF SURGICAL ONCOLOGY
• 影响因子: 3.7
• 作者: Sano, Akihiko;Kato, Hiroyuki;Kuwano, Hiroyuki
• 通讯作者: Kuwano, Hiroyuki

CD24 Expression is Associated with Progression of Gastric Cancer

• DOI: 10.5754/hge12763
• 发表时间: 2013-06-01
• 期刊: HEPATO-GASTROENTEROLOGY
• 作者: Takahashi, Masakazu;Nakajima, Masanobu;Kato, Hiroyuki
• 通讯作者: Kato, Hiroyuki

食道癌切除症例におけるCD24 発現の検討

食管癌切除病例中CD24表达的检测

• 发表时间: 2011
• 作者: Nakajima M;Kato H;Miyazaki T;FukuchiM;Masuda N;Fukai Y;Sohda M;Ahmad F;Kuwano H;佐野 彰彦
• 通讯作者: 佐野 彰彦

Comprehensive Analysis of Genes Involved in the Malignancy of Gastrointestinal Stromal Tumors

胃肠道间质瘤恶性相关基因的综合分析

• 发表时间: 2010
• 期刊: Anticancer Research
• 影响因子: 2
• 作者: Hadisaputri YE;Miyazaki T;Suzuki S;Yokobori T;Kobayashi T;Tanaka N;Inose T;Sohda M;Kuwano H.;Tsumuraya M
• 通讯作者: Tsumuraya M

胃癌におけるCD24 発現と臨床病理学的検討

胃癌中CD24的表达及临床病理学检查

• 发表时间: 2011
• 作者: Yamauchi H;Asao T;Yazawa S;Kigure W;Morita H;Kobayashi T;Kato T;Yajima R;Tabe Y;Yamaki S;Fukasawa T;Fujii T;Tsutsumi S;Kuwano H;高橋 雅一
• 通讯作者: 高橋 雅一