The identification of molecular mechanisms of androgen receptor regulation and novel therapeutic target in prostate cancer

雄激素受体(AR)在前列腺癌中的功能分析对于阐明去势抵抗前列腺癌(CRPC)的发生机制至关重要。我们发现氧化应激和活性氧在CRPC的发展过程中起着重要的作用。而转录因子Twist-1和YB-1就是在这种氧化应激的诱导下产生的，在调节AR向CRPC发展过程中起着重要的作用。此外，我们还得到了AR共激活剂的新的分子机制。此外，我们还发现了阿司匹林和他汀类药物在AR调节中的新药理作用。

The functional analysis of androgen receptor (AR) in prostate cancer is most important to clarify mechanisms of developing castration-resistant prostate cancer (CRPC). Weidentified that oxidative stress and reactive oxygen species had played an important role in the progression to CRPC. And the transcription factors, Twist-1 and YB-1, are induced by this oxidative stress and had significant function to regulate AR in developing to CRPC. In addition, we obtained the novel molecular mechanisms on AR co-activators. Furthermore, we found the novel pharmacological function of aspirin and statin on AR regulations.