Analysis of Protamin2deficient mouse

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Analysis of Protamin2deficient mouseIn the human male infertility, abnormal expression of sperm cell-specific expressionprotein protamine is often seen. Therefore, we've tried to analyze a protamine-2deficient mice by gene targeting method using mouse embryonic cells. Analysis ofprotamine-1 deficient mice to be male sterile in the chimeric mice and heterozygous micein protamine-2 deficient mice was expected.Therefore, by using the gene targeting intoES cells without chromosome Y, to generate mutant mice, we challenged strains ofgerm-deficient mutant mice