Alteration of tumor immunity and anti-cancer drug / hormone sensitivity accompanied by MMR mechanism abnormality in endometrial cancer

子宫内膜癌伴随MMR机制异常的肿瘤免疫及抗癌药物/激素敏感性改变

• 批准号: 22591867
• 负责人: SUSUMU Nobuyuki
• 金额: $ 2.83万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591867/
• 关键词: 婦人科腫瘍学; 子宮内膜癌; 腫瘍免疫; MMR機構; ホルモン感受性; 黄体ホルモン療法

We detected that those cases with endometrial cancer with many infiltrative regulatory T cells (Treg) were significantly poorly-differentiated or advanced-stage cancer and had poor prognosis, and that those cases with high Treg/CD8 ratio had poor prognosi

我们发现，那些浸润性调节性T细胞（Treg）较多的子宫内膜癌病例是明显低分化或晚期癌症，预后不良，而那些Treg/CD 8比值较高的病例，其预后不良。

项目成果

New candidate therapeutic agents for endometrial cancer: potential for clinical practice (review).

• DOI: 10.3892/or.2013.2221
• 发表时间: 2013-03
• 期刊: Oncology reports
• 影响因子: 4.2
• 作者: Umene K;Banno K;Kisu I;Yanokura M;Nogami Y;Tsuji K;Masuda K;Ueki A;Kobayashi Y;Yamagami W;Tominaga E;Susumu N;Aoki D
• 通讯作者: Aoki D

Association of epigenetic inactivation of the WRN gene with anticancer drug sensitivity in cervical cancer cells.

• DOI: 10.3892/or.2012.1912
• 发表时间: 2012-10
• 期刊: Oncology reports
• 影响因子: 4.2
• 作者: Masuda K;Banno K;Yanokura M;Tsuji K;Kobayashi Y;Kisu I;Ueki A;Yamagami W;Nomura H;Tominaga E;Susumu N;Aoki D
• 通讯作者: Aoki D

Complete remission of recurrent and refractory uterine epithelioid leiomyosarcoma using weekly administration of bevacizumab and temozolomide

每周给予贝伐珠单抗和替莫唑胺可完全缓解复发性难治性子宫上皮样平滑肌肉瘤

• DOI: 10.1016/j.ejogrb.2011.02.020
• 发表时间: 2011
• 期刊: Eur J Obstet Gynecol Reprod Biol.
• 作者: Takano M;Kikuchi Y;Susumu N;et al
• 通讯作者: et al

How long can young women with endometrial cancer be safely treated with MPA for fertility-preserving?-from a retrospective analysis of 88 cases-

年轻子宫内膜癌女性接受MPA保育多久可以安全？-来自88例的回顾性分析-

• 发表时间: 2011
• 作者: Susumu N;Yamagami Y;Ichikawa Y;et al
• 通讯作者: et al

IndiaChemotherapeutic strategies for gynecological cancers

印度妇科癌症的化疗策略

• 发表时间: 2010
• 作者: Susumu N;Saito E;Nomura H;et al
• 通讯作者: et al